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Application of epigallocatechin gallate and derivatives thereof in preparing drugs for resisting against zika virus

A technology of epigallocatechin and gallate, applied in the field of application of epigallocatechin gallate and its derivatives in the preparation of anti-Zika virus drugs, to achieve the purpose of inhibiting plaque effect and improving economic value Effect

Inactive Publication Date: 2019-04-26
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Epigallocatechin gallate (EGCG) is a flavonoid compound extracted from Chinese green tea. Adenovirus, HIV, HPV, Epstein-Barr virus and many other viruses have obvious inhibitory effects, and are expected to become a broad-spectrum antiviral drug. There are no relevant reports on its application in anti-Zika virus drugs

Method used

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  • Application of epigallocatechin gallate and derivatives thereof in preparing drugs for resisting against zika virus
  • Application of epigallocatechin gallate and derivatives thereof in preparing drugs for resisting against zika virus
  • Application of epigallocatechin gallate and derivatives thereof in preparing drugs for resisting against zika virus

Examples

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Embodiment Construction

[0033] Examples are further listed below to describe the present invention in detail. It should also be understood that the following examples are only used to further illustrate the present invention, and should not be construed as limiting the protection scope of the present invention. Some non-essential improvements and adjustments made by those skilled in the art according to the principles set forth in the present invention all belong to the present invention scope of protection. The specific process parameters and the like in the following examples are only examples of the appropriate range, that is, those skilled in the art can make a selection within the appropriate range through the description herein, and are not limited to the specific data exemplified below.

[0034] The cells used in the present invention are African green monkey kidney cells (Vero cells), which are cultured in DMEM medium containing 10% fetal bovine serum, 100U / L penicillin and streptomycin;

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Abstract

The invention discloses an application of epigallocatechin gallate and derivatives thereof in preparing drugs for resisting against zika virus. The epigallocatechin gallate has obvious anti-zika virusactivity, is capable of obviously restraining plaque effect caused by zika virus infection, mRNA and protein expression level and NS2B-NS3 protease activity and can achieve a 100% restraining effectby acting in an entering stage of zika virus; EGCG has low toxicity to cells and almost has no toxicity to Vero cells in concentration range of 0-50 MuM; IC50 of EGCG to zika virus is 18.23+ / -3.11nM and safety index is more than 2000. The invention develops a new application of EGCG, increases an economic value of EGCG and provides a theory and practice basis for application of EGCG in preparing drugs for resisting against zika virus.

Description

technical field [0001] The present invention relates to the application of epigallocatechin gallate and derivatives thereof, in particular to the application of epigallocatechin gallate and derivatives thereof in preparing anti-Zika virus drugs. Background technique [0002] Zika virus is a mosquito-borne virus that was first identified in monkeys in Uganda in 1947 by a yellow fever surveillance network, and was later confirmed in humans in Uganda and the United Republic of Tanzania in 1952. The most recent and most serious outbreak occurred in Brazil in 2015, and as of March 2017, host-transmitted Zika virus infection has been confirmed in at least 84 countries and regions. According to reports, Zika virus infection can cause nervous system disorders, including Guillain-Barré syndrome, meningoencephalitis, and myelitis. The group most affected by Zika virus is pregnant women. Microcephaly. The scientists also found that Zika virus can cause testicular damage and ultimatel...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P31/14
CPCA61K31/353A61P31/14Y02A50/30
Inventor 邹敏柳红妙姚新刚周春琼柯昌文杨海涛刘叔文
Owner SOUTHERN MEDICAL UNIVERSITY
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