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Application of myricetin and derivative thereof in preparing drug for resisting zika virus

A technology of Zika virus and its derivatives, which can be applied in antiviral agents, vector-borne disease resistance, and pharmaceutical formulations, etc. It can solve problems affecting lymphocyte activation and proliferation, achieve the effect of inhibiting plaque effect and improving economic value

Inactive Publication Date: 2019-04-26
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Myricetin is a flavonoid compound extracted from the fruit of Myrica rubra, which has various functions such as scavenging free radicals, anti-oxidation, anti-tumor, and affecting the activation and proliferation of lymphocytes, but it has not been related to anti-Zika virus drugs. to report

Method used

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  • Application of myricetin and derivative thereof in preparing drug for resisting zika virus
  • Application of myricetin and derivative thereof in preparing drug for resisting zika virus
  • Application of myricetin and derivative thereof in preparing drug for resisting zika virus

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Embodiment Construction

[0033] Examples are further listed below to describe the present invention in detail. It should also be understood that the following examples are only used to further illustrate the present invention, and should not be construed as limiting the protection scope of the present invention. Some non-essential improvements and adjustments made by those skilled in the art according to the principles set forth in the present invention all belong to the present invention scope of protection. The specific process parameters and the like in the following examples are only examples of the appropriate range, that is, those skilled in the art can make a selection within the appropriate range through the description herein, and are not limited to the specific data exemplified below.

[0034] The cells used in the present invention are African green monkey kidney cells (Vero cells), which are cultured in DMEM medium containing 10% fetal bovine serum, 100U / L penicillin and streptomycin;

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Abstract

The invention discloses application of myricetin and a derivative thereof in preparing a drug for resisting zika virus. An experiment verifies that the myricetin has obvious anti-zika virus activity,is capable of obviously inhibiting a plaque effect generated by zika virus infection, mRNA (messenger Ribonucleic Acid) and protein expression level and the activity of NS2B-NS3 protease and acts on azika virus entry stage, and a 100 percent inhibition effect can be achieved. The toxicity of the myricetin to cells is smaller, and the myricetin basically has no toxicity on Vero cells within a concentration range of 0 to 50 muM. IC50 of the myricetin to the zika virus is 0.576+ / -0.173 muM, and the safety index is greater than 100. According to the application disclosed by the invention, new application of the myricetin is developed, the economic value of the myricetin is increased, and theoretical and practical basis is provided for the application of the myricetin in preparing the drug forresisting the zika virus.

Description

technical field [0001] The present invention relates to the application of myricetin and its derivatives, in particular to the application of myricetin and its derivatives in the preparation of anti-Zika virus drugs. Background technique [0002] Zika virus is a mosquito-borne virus first identified in monkeys in Uganda in 1947 and confirmed in humans in 1952. In 2015, due to the outbreak of a large-scale infection in Brazil and its spread around the world, it attracted widespread attention. As of March 2017, host-transmitted Zika virus infection has been confirmed in at least 84 countries and regions. The clinical symptoms of Zika virus infection are generally mild, and severe infection in adults can cause neurological disorders, including Guillain-Barré syndrome, meningoencephalitis and myelitis. The most affected groups are pregnant women, whose infection with the virus can cause fetal brain Developmental abnormalities known as microcephaly. Zika virus is transmitted b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P31/14
CPCA61K31/352A61P31/14Y02A50/30
Inventor 邹敏柳红妙李琳李晓娟柯昌文杨海涛刘叔文
Owner SOUTHERN MEDICAL UNIVERSITY
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