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A nano-microcapsule with lead-dispelling function and preparation method thereof

A technology of nano-microcapsules and functions, which is applied in the field of nano-microcapsules with lead-dispelling function and its preparation, which can solve the problems of low blood lead clearance rate, inconvenient storage, lack of essential elements, etc., and achieve good health care and lead-expelling Outstanding effect and high bioavailability

Active Publication Date: 2021-04-20
哈工大机器人(山东)智能装备研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing lead-expelling drugs: Calcium Edetate (Ca-EDTA), Ca-DTPA, Sodium Dimercaptosuccinate (NaDMS), combined with blood, liver, kidney, brain and other target organs The many metal ions in it produce a strong complexing force to form a complex, which is excreted with urine, feces, etc., but its side effect is that it can lead to the lack of various essential elements in the human body at the same time, and when the dosage is large, it can damage the kidneys, etc. Therefore, it is of great significance to develop a functional food or health food with the function of removing lead.
[0003] The currently developed functional foods with lead removal function mainly have problems such as inconvenient storage, irritation to the stomach, and low blood lead clearance rate, and it is difficult to achieve the ideal lead removal effect.

Method used

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  • A nano-microcapsule with lead-dispelling function and preparation method thereof
  • A nano-microcapsule with lead-dispelling function and preparation method thereof
  • A nano-microcapsule with lead-dispelling function and preparation method thereof

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specific Embodiment approach 1

[0028] A preparation method of nano-microcapsules with lead-dispelling function, comprising the steps of:

[0029] Step a, basic raw material processing: take onions, green onions, and garlic according to a certain number of parts by weight, remove the outer skin, wash away impurities, and mash, add absolute ethanol to the mixture according to a certain ratio of material to liquid, and extract with ultrasonic assistance to obtain extracts and residues respectively ,stand-by;

[0030] Step b, preparing a thick paste: the extract obtained in step a is spun to remove ethanol with a rotary evaporator to obtain a thick paste for use;

[0031] Step c. Preparation of polysaccharide powder: Weigh the residue obtained in step a, dry fungus powder, dry wolfberry powder, konjac powder, and kelp powder according to a certain number of parts by weight, add distilled water after mixing, ultrasonically assisted extraction, combine the obtained water extracts, and concentrate Add ethanol, ca...

specific Embodiment approach 2

[0046] A preparation method of nano-microcapsules with lead-dispelling function, comprising the steps of:

[0047] Step a, basic raw material processing: take onions, green onions, and garlic according to a certain number of parts by weight, remove the outer skin, wash away impurities, and mash, add absolute ethanol to the mixture according to a certain ratio of material to liquid, and extract with ultrasonic assistance to obtain extracts and residues respectively ,stand-by;

[0048] Step b, preparing a thick paste: the extract obtained in step a is spun to remove ethanol with a rotary evaporator to obtain a thick paste for use;

[0049] Step c. Preparation of polysaccharide powder: Weigh the residue obtained in step a, dry fungus powder, dry wolfberry powder, konjac powder, and kelp powder according to a certain number of parts by weight, add distilled water after mixing, ultrasonically assisted extraction, combine the obtained water extracts, and concentrate Add ethanol, ca...

specific Embodiment approach 3

[0064] A preparation method of nano-microcapsules with lead-dispelling function, comprising the steps of:

[0065] Step a, basic raw material processing: take onions, green onions, and garlic according to a certain number of parts by weight, remove the outer skin, wash away impurities, and mash, add absolute ethanol to the mixture according to a certain ratio of material to liquid, and extract with ultrasonic assistance to obtain extracts and residues respectively ,stand-by;

[0066] Step b, preparing a thick paste: the extract obtained in step a is spun to remove ethanol with a rotary evaporator to obtain a thick paste for use;

[0067] Step c. Preparation of polysaccharide powder: Weigh the residue obtained in step a, dry fungus powder, dry wolfberry powder, konjac powder, and kelp powder according to a certain number of parts by weight, add distilled water after mixing, ultrasonically assisted extraction, combine the obtained water extracts, and concentrate Add ethanol, ca...

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Abstract

The invention discloses a nano-microcapsule with lead-dispelling function and a preparation method thereof, belonging to the field of nano-microcapsules. The purpose of the invention is to solve the problem of effective lead discharge from the human body. The basic raw material of the present invention is assisted with absolute ethanol ultrasonic extraction to obtain the extract and residue, prepare thick paste and polysaccharide powder, dissolve the thick paste, soybean lecithin, and cholesterol in absolute ethanol to obtain a fat-soluble solution, and prepare the water-soluble solution, Vitamin C, taurine, L-cysteine, stachyose make water-soluble solution, obtain liposome suspension after homogeneous then, drip in the chitosan solution of certain volume under the condition of stirring, After filtering with a microporous membrane, drying with a spray dryer to obtain nanometer microcapsules. The invention uses onion, green onion, garlic, fungus, wolfberry, konjac powder, and kelp as raw materials, uses the lead-expelling active ingredient as the capsule core, and chitosan as the wall material, has good stability, high bioavailability, and slow-release effect. The role of continuous lead discharge is outstanding.

Description

technical field [0001] The invention belongs to the field of nanometer microcapsules; in particular, it relates to a nanometer microcapsule with the function of driving lead and a preparation method thereof. Background technique [0002] Lead is a trace element widely distributed in nature, with a content of 0.0016% in the earth's crust, ranking 35th in the abundance of elements in the earth's crust. Due to human activities, lead is constantly migrating to the atmosphere, hydrosphere and biosphere. Human beings ingest lead through breathing lead-containing dust, drinking water pollution and eating vegetables with accumulated lead. Since the human body cannot metabolize lead, the accumulated lead in the body will have a negative impact on the body. have a certain impact. Existing lead-expelling drugs: Calcium Edetate (Ca-EDTA), Ca-DTPA, Sodium Dimercaptosuccinate (NaDMS), combined with blood, liver, kidney, brain and other target organs The many metal ions in it produce a s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K36/8962A61P39/02A61K9/127A23L33/105A23L33/125A23L33/175A23L33/15A61K31/185A61K31/198A61K31/375A61K31/702A61K31/715A61K36/03A61K36/07A61K36/815A61K36/888
CPCA61K9/127A61K9/5161A61K31/185A61K31/198A61K31/375A61K31/702A61K31/715A61K36/03A61K36/07A61K36/815A61K36/888A61K36/8962A23L33/105A23L33/125A23L33/15A23L33/175A61P39/02A61K2300/00
Inventor 卢卫红朱云峰徐翠翠金少瑾孙胜楠张友源周凯
Owner 哈工大机器人(山东)智能装备研究院