A mesoporous titanium peroxide nanomedicine composition with lung cancer targeting and enhanced photodynamic therapy effect and preparation method thereof

A technology of mesoporous titanium peroxide and photodynamic therapy, which is applied in the field of pharmaceutical preparations, can solve problems such as the increase of ROS ability, achieve the effects of preventing drug leakage, reasonable design, and enhancing the effect of photodynamic therapy

Active Publication Date: 2021-07-02
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, studies have proved that titanium dioxide becomes titanium peroxide after oxidation, and the ability to generate ROS will be greatly increased.
[0006] In summary, there is currently no composition that combines many factors together to treat lung cancer

Method used

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  • A mesoporous titanium peroxide nanomedicine composition with lung cancer targeting and enhanced photodynamic therapy effect and preparation method thereof
  • A mesoporous titanium peroxide nanomedicine composition with lung cancer targeting and enhanced photodynamic therapy effect and preparation method thereof
  • A mesoporous titanium peroxide nanomedicine composition with lung cancer targeting and enhanced photodynamic therapy effect and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A method for preparing a mesoporous titanium peroxide nano-medicine composition capable of targeting lung cancer and enhancing the effect of photodynamic therapy, comprising the following steps:

[0044] The first step is to synthesize mesoporous titanium peroxide nanoparticles

[0045] 1.1) Add 20ml of absolute ethanol and 100μl of n-heptanoic acid into a beaker and stir for 5min. After thorough mixing, 300 μl of titanium source tetrabutyl titanate was added and stirring was continued for 15 minutes. Finally, 5ml of deionized water was added, and stirring was continued for 20min.

[0046] 1.2) Put the reacted solution in a reaction kettle and heat it with water at 120°C for 40 minutes. The obtained reaction solution was washed twice with absolute ethanol and deionized water, and dried to obtain mesoporous titanium dioxide nanoparticles.

[0047] 1.3) Weigh 10 mg of mesoporous titanium dioxide nanoparticles into a beaker, add 0.5 ml of hydrogen peroxide and mix and s...

Embodiment 2

[0076] A method for preparing a mesoporous titanium peroxide nano-medicine composition capable of targeting lung cancer and enhancing the effect of photodynamic therapy, comprising the following steps:

[0077] The first step is to synthesize mesoporous titanium peroxide nanoparticles

[0078] 1.1) Add 20ml of absolute ethanol and 50μl of n-heptanoic acid into a beaker and stir for 10min. After fully mixing, add 400 μl of titanium source tetrabutyl titanate and continue stirring for 20 min. Finally, 10ml of deionized water was added, and stirring was continued for 30min.

[0079] 1.2) Put the reacted solution in a reaction kettle and heat it with water at 110°C for 50 minutes. The obtained reaction solution was washed twice with absolute ethanol and deionized water, and dried to obtain mesoporous titanium dioxide nanoparticles.

[0080] 1.3) Weigh 10 mg of mesoporous titanium dioxide nanoparticles into a beaker, add 0.7 ml of hydrogen peroxide and mix and stir for 2 hours u...

Embodiment 3

[0088] A method for preparing a mesoporous titanium peroxide nano-medicine composition capable of targeting lung cancer and enhancing the effect of photodynamic therapy, comprising the following steps:

[0089] The first step is to synthesize mesoporous titanium peroxide nanoparticles

[0090] 1.1) Add 20ml of absolute ethanol and 70μl of n-heptanoic acid into a beaker and stir for 5min. After thorough mixing, 350 μl of titanium source tetrabutyl titanate was added and stirring was continued for 15 minutes. Finally, 8ml of deionized water was added, and stirring was continued for 25min.

[0091] 1.2) Put the reacted solution in a reaction kettle and heat it with water at 130°C for 45 minutes. The obtained reaction solution was washed twice with absolute ethanol and deionized water, and dried to obtain mesoporous titanium dioxide nanoparticles.

[0092] 1.3) Weigh 10 mg of mesoporous titanium dioxide nanoparticles into a beaker, add 1 ml of hydrogen peroxide and mix and stir...

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Abstract

A mesoporous titanium peroxide nano-medicine composition capable of targeting lung cancer and enhancing the effect of photodynamic therapy and a preparation method thereof belong to the field of pharmaceutical preparations. First synthesize mesoporous titanium peroxide nanoparticles, then synthesize aminated mesoporous titanium peroxide loaded with anti-tumor drug doxorubicin, and finally synthesize surface-modified polyethylene glycol PEG and targeting polypeptide YSA with lung cancer targeting And a mesoporous titanium peroxide nano drug composition that enhances the effect of photodynamic therapy. In the present invention, mesoporous titanium peroxide is selected to efficiently carry antitumor drug doxorubicin and further modify the outer surface; by X-ray irradiation, the titanium peroxide carrier produces a relatively high amount of active oxygen, which cooperates with the carried doxorubicin, Realize the combined effect of photodynamic therapy and chemotherapy to improve the killing ability of tumor cells; surface modification targeting polypeptide YSA to achieve specific recognition and targeted delivery of non-small cell lung cancer cells with high expression of EphA2.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and provides a mesoporous titanium peroxide nano-medicine composition capable of targeting lung cancer and enhancing the effect of photodynamic therapy and a preparation method thereof. [0002] technical background [0003] In recent years, due to the aging population and increasing air pollution, the incidence and mortality of malignant tumors have increased year by year, and it has become the number one killer of human health, among which the incidence and mortality of lung cancer rank first among malignant tumors , so the study of lung cancer has very important practical significance. [0004] In the clinical treatment of lung cancer, chemotherapy is still one of the main means. However, many chemotherapeutic drugs have problems such as low selectivity, easy clearance by the reticuloendothelial system, rapid metabolism in the body, and severe side effects, which limit the clinical a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K31/704A61K41/00A61K47/60A61K47/64A61P35/00
CPCA61K31/704A61K41/0057A61K47/60A61K47/64A61K47/6949A61P35/00A61K2300/00
Inventor 郭兆明郑坤谭振权刘晔程笑马昆崔昌浩王黎
Owner DALIAN UNIV OF TECH
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