Composition containing buffer

Abstract

Provided is a composition containing a buffer, the composition being used when a chelation targeting agent is labeled by 90Y, 153Sm, 165Dy, 165Er, 166Ho, or 177Lu. One or more buffers selected from benzoic acid, maleic acid, fumaric acid, succinic acid, and salts thereof are contained in a composition containing a chelation targeting agent.

Description

technical field [0001] The invention relates to a buffer-containing composition for preparing a radiometal-labeled chelated targeting agent. Background technique [0002] Radiopharmaceuticals used in nuclear medicine have a form called a kit and a form called an injection. The kit is a composition for preparing an injection to be administered to humans by reacting a radioactive metal with a chelated targeting agent in clinical medicine, and is composed of at least the radioactive metal and the chelated targeting agent accommodated separately therefrom. On the other hand, injections are compositions prepared in such a way that they can be administered directly in clinical medicine. [0003] The radioactive metal constituting the kit is usually provided in the form of a hydrochloric acid solution with a pH of about 1. For example, in the kit constituting the RI-labeled antibody therapy preparation Zevalin (registered trademark) 111 In or 90 In Y, an appropriate amount of h...

AI Technical Summary

Problems solved by technology

This shows that in the chelate coordination using radioactive metals, the citrate buffer is suitable for indium but not for gallium, and there are cases where the buffer is suitable and unsuitable for each radioactive metal.

[0009] In addition, kits are sometimes in the form of lyophilized preparations, but acetic acid buffer cannot be selected as the buffer because widely used acetic acid buffer sublimes during the lyophilization process

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