Vaccine container with failure indicator and failure indication method thereof

A technology of indicators and vaccines, applied in instruments, scientific instruments, thermometers with physical/chemical changes, etc., can solve problems such as no definite and achievable solution, inappropriate temperature control, difficult monitoring, etc., to reduce the loss of vaccines , Reduce vaccination accidents and improve safety

Pending Publication Date: 2019-04-23
刘永奇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this technology, the phase change layer uses ferric ions. When the ambient temperature is lower than 9°C, the inorganic phase change heat storage material is in a solid state. When the ambient temperature reaches 9°C, the inorganic phase change heat storage material begins to change from solid to solid state. However, the technology does not give a definite solution. How to configure ferric ions can realize the phase transition at 9°C. There is no similar technology in the existing technology, and the temperature of 9°C has been used for a long time for vaccines. lead to failure, the temperature control of the technology is not suitable
In addition, this technology is also a way of labeling, which is easy to replace and difficult to monitor

Method used

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  • Vaccine container with failure indicator and failure indication method thereof
  • Vaccine container with failure indicator and failure indication method thereof
  • Vaccine container with failure indicator and failure indication method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A preparation method of failure indicator, comprising the steps of:

[0049] 1) Preparation of component A: Add 5 g of propylene glycol monostearate into 75 g of n-tetradecane at a temperature of 25° C., and mix evenly with a magnetic stirrer. While stirring, 5 g of sodium carbonate solution with a mass fraction of 5% was added dropwise, and the stirring was continued for 30 min. After the mixture was placed in a -5°C environment for 2 hours, it was pulverized with a pulverizer to obtain component A.

[0050] 2) Preparation of component B: Add 1 g of sorbitan sesquioleate into 80 g of n-tetradecane at a temperature of 25° C., and mix evenly with a magnetic stirrer. Add 1 g of phenolphthalein indicator (mass ratio: phenolphthalein: ethanol: water = 1:94:5) dropwise while stirring, and continue stirring for 40 min. After the mixture was placed at -3°C for 3 h, it was pulverized with a pulverizer to obtain component B.

[0051] 3) In the -5°C environment, mix component ...

Embodiment 2

[0053] A preparation method for failure indicator, comprising the steps of:

[0054] 1) Preparation of component A: Add 2g of diethylene glycol monooleate into 90g of n-decyl alcohol at a temperature of 25°C, and mix evenly with a magnetic stirrer. While stirring, 10 g of 1% sodium hydroxide solution was added dropwise, and the stirring was continued for 60 min. After the mixture was placed in an environment at 3° C. for 5 h, it was pulverized with a pulverizer to obtain component A.

[0055] 2) Preparation of component B: at a temperature of 25°C, 7g of glyceryl monostearate was added to 95g of n-decyl alcohol, and mixed uniformly with a magnetic stirrer. While stirring, 5 g of phenolphthalein indicator (mass ratio: phenolphthalein: ethanol: water = 2:90:8) was added dropwise and continued to stir for 60 min. After the mixture was placed in an environment of 0° C. for 4 h, it was pulverized with a pulverizer to obtain component B.

[0056] 3) In an environment of 0°C, mix ...

Embodiment 3

[0058] A preparation method of failure indicator, comprising the steps of:

[0059] 1) Preparation of component A: Add 6 g of sorbitan fatty acid ester to 80 g of methyl tridecanoate at a temperature of 25° C., and mix evenly with a magnetic stirrer. While stirring, 20 g of 3% sodium bicarbonate solution was added dropwise, and the stirring was continued for 45 min. After the mixture was placed at -1°C for 2 hours, it was pulverized with a pulverizer to obtain component A.

[0060] 2) Preparation of component B: Add 0.5 g of sorbitan sesquioleate into 90 g of methyl tridecanoate at a temperature of 25° C., and mix evenly with a magnetic stirrer. Add 2.5 g of phenolphthalein indicator dropwise while stirring (mass ratio: phenolphthalein: ethanol: water = 2:93:5) and continue stirring for 30 min. After the mixture was placed at -2°C for 5 hours, it was pulverized with a pulverizer to obtain component B.

[0061] 3) In an environment of -2°C, mix component A and component B un...

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Abstract

The invention discloses a vaccine container with a failure indicator and a failure indication method thereof. The vaccine container comprises a vaccine bottle, the failure indicator and a failure indicator box. The failure indicator box is of a sealed cavity structure, and the failure indicator is arranged in a cavity of the failure indicator box; the failure indicator box is fixedly connected tothe vaccine bottle. The failure indicator is obtained by uniformly mixing a component A and a component B. A raw material of the component A comprises a phase change heat storage material, an alkali solution and an emulsifier; a raw material of the component B comprises the same phase change heat storage material as the component A, a phenolphthalein indicator and an emulsifier; and the phase change temperature of the phase change heat storage material is 2-8 DEG C. The vaccine container with the failure indicator can absorb the heat in the environment, control the temperature rise of vaccine,and improve the stability of the vaccine transportation process, and when the temperature exceeds 8 DEG C, the failure indicator turns red, whether the vaccine is failed or not can be indicated, andthe safety of the vaccination is ensured.

Description

technical field [0001] The invention relates to vaccine effectiveness indication, in particular to a vaccine container with an invalidation indicator and an invalidation indication method thereof. Background technique [0002] In March 2016, a case of illegal vaccine transportation occurred in Shandong, which shocked the whole country. The state issued an administrative order for vaccine transportation, requiring local governments to earnestly perform their supervisory duties. my country's "Regulations on the Administration of Vaccine Circulation and Vaccination" has clear requirements for the storage and transportation of vaccines. The storage and transportation of vaccines must be carried out in strict accordance with temperature requirements to prevent high-temperature exposure of vaccines. The purpose is to ensure the effectiveness of vaccines to the greatest extent. All kinds of vaccines used for vaccination are sensitive to heat and light, and most vaccines are relativ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01K11/16
CPCG01K11/16
Inventor 刘永奇周立新
Owner 刘永奇
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