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Digital biomarkers for cognition and movement diseases or disorders

A technology for sports diseases and disorders, applied in the field of diagnosis, which can solve time-consuming and other problems

Active Publication Date: 2019-04-26
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such a reliable and efficient diagnosis currently requires the presence of a medical practitioner for neurological evaluation or the application of expensive and time-consuming imaging methods in, for example, hospitals

Method used

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  • Digital biomarkers for cognition and movement diseases or disorders
  • Digital biomarkers for cognition and movement diseases or disorders
  • Digital biomarkers for cognition and movement diseases or disorders

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0442] Example 1: Computer-implemented (electronic) Symbolic Digital Modal Testing (eSDMT)

[0443] A smartphone with a 5.1-inch screen is programmed with the kit for performing the eSDMT test. The tester is asked to perform the test on the smartphone according to the instructions shown on the display. 30 subjects were investigated. The determined response and accuracy are shown in the Figure 4 middle.

[0444] The time elapsed between subsequent response (R) and subsequent correct response (CR) was also investigated in the implemented eSDMT test. The results are shown in Figure 5 middle.

[0445] In addition, response (R) and correct response (CR) profiles were determined. Examples of Response (R) and Correct Response (CR) profiles of two subjects with distinctly different performances on the eSDMT test are shown in Figure 6 middle.

example 2

[0446] Example 2: Computer-implemented test to assess fine motor skills (fine motor assessment), particularly hand motor function, and specifically the touchscreen-based "draw shape" and "squeeze shape" tests

[0447] A smartphone with a 5.1-inch screen was programmed with a suite for performing the "draw shape" and "squeeze shape" tests. The tester is asked to perform the test on the smartphone according to the instructions shown on the display.

[0448] In the pinch shape setup, touch events from the first and second fingers are determined and the distance and velocity of the pinch events are calculated ( Figure 8 ). In the drawing shape setting, a circle-shaped touch trace is defined. The results are plotted in Figure 8 or Figure 10 middle.

[0449] The overall calculated trace performance is shown separately in Figure 9 and Figure 11 , and detailed data are summarized in Table 1 or Table 2 below.

[0450] Table 1: Circle evaluation readout performance statisti...

example 3

[0455] Example 3: Results from a prospective pilot study (FLOODLIGHT) to evaluate the feasibility of using digital technologies for remote patient monitoring in patients with multiple sclerosis

[0456] Study populations will be selected by using the following inclusion and exclusion criteria:

[0457] Key inclusion criteria:

[0458] Sign the informed consent

[0459] Able to comply with the study protocol, in the investigator's judgment

[0460] Age 18-55, including 18 and 55

[0461] Diagnosed with MS, confirmed according to revised McDonald 2010 guidelines

[0462] EDSS score from 0.0 to 5.5 inclusive

[0463] Weight: 45-110kg

[0464] For women of reproductive potential: Agree to use an acceptable method of contraception during the study period

[0465] Key strikeout guidelines:

[0466] Patients who, in the judgment of the investigator, are seriously ill and unstable

[0467] Change dosing regimen or switch disease-modifying therapy (DMT) within the last 12 weeks...

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Abstract

The present invention relates to the field of diagnostics. More specifically, it concerns a method for assessing a cognition and movement disease or disorder in a subject suspected to suffer therefromcomprising the steps of determining at least one cognition and / or fine motoric activity parameter from a dataset of cognition and / or fine motoric activity measurements obtained from said subject using a mobile device and comparing the determined at least one cognition and / or fine motoric activity parameter to a reference, whereby the cognition and movement disease or disorder will be assessed. The present invention also relates to a method for identifying whether a subject will benefit from a therapy for a cognition and movement disease or disorder comprising the steps of the method of the aforementioned invention and the further step of identifying the subject as a subject that benefits from the therapy if the cognition and movement disease or disorder is assessed. The present inventioncontemplates a mobile device comprising a processor, at least one sensor and a database as well as software which is tangibly embedded to said device and, when running on said device, carries out themethod of the present invention, a system comprising a mobile device comprising at least one sensor and a remote device comprising a processor and a database as well as software which is tangibly embedded to said device and, when running on said device, carries out the method and the use of the mobile device or system according to the invention for assessing a cognition and movement disease or disorder in a subject.

Description

technical field [0001] The present invention relates to the field of diagnostics. More specifically, the present invention relates to a method for assessing a cognitive and motor disease or disorder in a subject suspected of having the disease, comprising the steps of: and / or fine motor activity measurements in the dataset to determine at least one cognitive and / or fine motor activity parameter; and comparing the determined at least one cognitive and / or fine motor activity parameter with a reference value, thereby evaluating the Cognitive and motor disorders or disorders described above. The present invention also relates to a method for identifying whether a subject would benefit from a therapy for a cognitive and motor disease or disorder, comprising the steps of the method of the foregoing invention and identifying said subject as Cognitive and motor diseases or disorders are evaluated as a further step for subjects who would benefit from the therapy. The present inventi...

Claims

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Application Information

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IPC IPC(8): A61B5/11A61B5/00A61B5/16
CPCA61B5/6898A61B5/7475A61B5/1101A61B5/1124A61B5/168A61B5/4088A61B5/7264A61B5/024A61B5/055A61B5/1118A61B5/1125A61B5/165A61B5/4082A61B5/4005A61B5/4029A61B5/4839A61B5/4848A61B5/486
Inventor M.巴克S.M.贝拉切夫C.戈森斯M.林德曼
Owner F HOFFMANN LA ROCHE & CO AG
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