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Pharmaceutical composition for treating psoriasis

A composition and psoriasis technology, applied in the field of drugs containing organic compounds, can solve the problems of side effects, expensive biological agents, easy to form drug resistance and dependence, etc., and achieve easy preparation, good quality control, and effective significant effect

Active Publication Date: 2019-05-03
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs can play a certain therapeutic role in clinical practice, but they will cause side effects after long-term use, and are prone to drug resistance and dependence. Biological agents are expensive and bring huge economic burdens to patients.

Method used

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  • Pharmaceutical composition for treating psoriasis
  • Pharmaceutical composition for treating psoriasis
  • Pharmaceutical composition for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Weigh 20 g of Qin Pi B and 20 g of betulinic acid by weight, mix them evenly, add 80 g of powdered sugar, 52 g of dextrin, 48 g of lactose and an appropriate amount of 65% ethanol to make a soft material, sieving to make granules, and drying at 60°C under normal pressure , After granulation, use packaging equipment to pack it into granules, 1g per bag. The granules are taken orally, 1 bag each time, once a day, 7 days as a course of treatment, and can be used continuously for 2-3 courses.

Embodiment 2

[0068] Weigh 22 g of Qin Pi B and 18 g of betulinic acid by weight, mix them evenly, add 80 g of powdered sugar, 52 g of dextrin, 48 g of lactose and an appropriate amount of 65% ethanol to make a soft material, sieving to make granules, and drying at 60°C under normal pressure After sizing, add 6.6 g of 3% magnesium stearate in the amount of granules, mix well, and then press the granules into 440 tablets with a punching device. The tablet is taken orally, 2 tablets each time, once a day, 7 days as a course of treatment, and can be used continuously for 2-3 courses.

Embodiment 3

[0070] Weigh 18 g of Qin Pi B and 22 g of betulinic acid by weight, mix them evenly, add 80 g of powdered sugar, 52 g of dextrin, 48 g of lactose and an appropriate amount of 65% ethanol to make a soft material, sieving to make granules, and drying at 60°C under normal pressure , Filled into No. 3 empty capsules after being whole, each capsule weighs 500mg on average. The capsule is taken orally, 2 capsules each time, once a day, 7 days as a course of treatment, and can be used continuously for 2-3 courses.

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Abstract

The present invention designs a pharmaceutical composition for treating psoriasis. The pharmaceutical composition comprises active ingredients and a medically acceptable adjuvant. The pharmaceutical composition is characterized by consisting of the following chemical compositions in weight percentages: 45%-55% of aesculetin and 45%-55% of betulinic acid. The pharmaceutical composition can significantly improve PASI score of back skin of psoriasis model mice, reduces epidermal thickening and weight loss of the mice, up-regulates a proportion of regulatory T cells (Treg) in the mice, and is remarkable in psoriasis treating effects.

Description

Invention field [0001] The present invention relates to medical preparations, in particular to medicines containing organic compounds, which can be used to treat psoriasis. Background technique [0002] Psoriasis, also known as psoriasis, is one of the most common chronic inflammatory skin diseases. Its condition is stubborn and easy to relapse. It can cause systemic damage. Its main histopathological manifestations are abnormal keratinocyte proliferation and incomplete keratinization. , Inflammatory cell infiltration and dermal tissue vascular proliferation, etc. At the same time, psoriasis is also prone to cause various complications such as psoriatic arthritis, metabolic syndrome, malignant tumors, etc., causing secondary harm to patients, seriously affecting the quality of life of patients, and even their life cycle. However, the exact pathogenesis of psoriasis is not yet clear. Studies have shown that the occurrence of psoriasis is related to many factors, including geneti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61K31/56A61P17/06
Inventor 卢传坚戴振华陈宇潮陈海明刘华桢刘翠华
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE