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Artemisia carvifolia biotransformation mycelium and extract and use thereof

A technology of biotransformation and mycelium, applied in biochemical equipment and methods, microorganisms, methods based on microorganisms, etc.

Inactive Publication Date: 2019-05-07
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, do not see the report that traditional Chinese medicine is applied to the anti-H.

Method used

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  • Artemisia carvifolia biotransformation mycelium and extract and use thereof
  • Artemisia carvifolia biotransformation mycelium and extract and use thereof
  • Artemisia carvifolia biotransformation mycelium and extract and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] An extract of Artemisia annua biotransformation mycelia, the preparation method comprising the steps of:

[0026] 9. (1) Take 490g of agricultural and sideline products wheat bran, 140g of corn flour, 70g of rice bran, and 300g of Chinese medicinal material Artemisia annua powder (Artemisia annua), mix well, add 500g of water and mix well, and obtain the culture medium of Hericium erinaceus . Then bottle, sterilize, insert Hericium erinaceus, transform and culture at 27°C for 40 days, take out the mycelium, and dry it to obtain the biotransformed mycelium of Artemisia annua; the biotransformed mycelium of Artemisia annua It contains fatty acid substances and sterone substances, the fatty acid substances include palmitic acid, linoleic acid, oleic acid and stearic acid; the sterone substances include ergosta-7,22-diene-3- ketone, stigmaster-4-ene-6α-ol-3-one, prosperidin, scopoletin, bik angelin; the content of palmitic acid in every 100g of the Artemisia annua biotrans...

Embodiment 2

[0030] An extract of Artemisia annua biotransformation mycelia, the preparation method comprising the steps of:

[0031](1) Get 420g of agricultural and sideline products wheat bran, 120g of corn flour, 60g of rice bran, and 400g of Chinese herbal medicine Artemisia annua powder (Artemisia annua), mix well, add 500g of water and mix well, and obtain the culture medium of Hericium erinaceus; Bottling, sterilizing, inserting Hericium erinaceus, transforming and culturing at 20°C for 40 days, taking out the mycelium, and drying to obtain the biotransformed mycelium of Artemisia annua; in the biotransformed mycelium of Artemisia annua Contain fatty acid substances and sterone substances, the fatty acid substances include palmitic acid, linoleic acid, oleic acid and stearic acid; the sterone substances include ergosta-7,22-dien-3-one , stigmaster-4-ene-6α-ol-3-ketone, prosperidin, scopoletin, bik angelin; the content of palmitic acid in every 100g of the Artemisia annua biotransfor...

Embodiment 3

[0035] An extract of Artemisia annua biotransformation mycelia, the preparation method comprising the steps of:

[0036] (1) Get 350g of agricultural and by-product wheat bran, 100g of corn flour, 50g of rice bran, and 500g of Chinese medicinal material Artemisia annua powder (Artemisia annua), mix well, add 500g of water and mix well, and obtain the culture medium of Hericium erinaceus; Bottling, sterilizing, inserting Hericium erinaceus, transforming and culturing at 25°C for 30 days, taking out the mycelium, and drying to obtain the biotransformed mycelium of Artemisia annua; in the biotransformed mycelium of Artemisia annua Contain fatty acid substances and sterone substances, the fatty acid substances include palmitic acid, linoleic acid, oleic acid and stearic acid; the sterone substances include ergosta-7,22-dien-3-one , stigmaster-4-ene-6α-ol-3-ketone, prosperidin, scopoletin, bik angelin; the content of palmitic acid in every 100g of the Artemisia annua biotransformat...

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Abstract

The present invention discloses an artemisia carvifolia biotransformation mycelium and an extract and a use thereof. A preparation method of the artemisia carvifolia biotransformation mycelium is as follows: hericium erinaceus is inoculated into a hericium erinaceus culture medium and cultured at 20-27 DEG C for 30-40 d, and mycelium is taken out and dried to obtain the artemisia carvifolia biotransformation mycelium; every 100 parts of the hericium erinaceus culture medium comprises 50-70 parts of a basal medium and 30-50 parts of artemisia carvifolia; the basal medium comprises the followingcomponents in parts by weight: 350-490 parts of wheat bran, 100-140 parts of corn flour, 50-70 parts of bran coat and 400-600 parts of water; the artemisia carvifolia biotransformation mycelium contains fatty acid substances and ketosteroid substances; and the fatty acid substances comprise palmitic acid, linoleic acid, oleic acid and stearic acid and the ketosteroid substances comprise ergost-7,22-diene-3-one, stigmasta-4-ene-6-alpha-ol-3-one, praeruptorin, scopoletin and byakangelicin. The extract of the artemisia carvifolia biotransformation mycelium has an anti-helicobacter pylori effect,has the effect obviously better than that of hericium erinaceus mycelium or artemisia carvifolia, and can be used for preparing an anti-helicobacter pylori drug.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to an annua biotransformation mycelium and its extract and application. Background technique [0002] Hericium erinaceus, a mushroom (fungi) of the family Hericium erinaceae, has been used in traditional Chinese medicine to treat gastrointestinal diseases for more than 2,000 years. A series of small molecule compounds, such as erinacines, are believed to have nerve regeneration and can pass through The blood-brain barrier repairs damaged nervous tissue. Hericium erinaceus also has anti-ulcer, anti-inflammatory, anti-microbial, immune regulation, improving liver function, anti-aging, lowering blood sugar and blood lipids, improving anti-hypoxia ability, increasing cardiac output, and improving circulation, etc., including Hericium erinaceus The medical preparations of are widely used in China. [0003] The most important active substances in Hericium erinaceus mycelia ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P1/02A61K36/282A61P31/04C12R1/645
Inventor 何述金周代俊黄俊豪
Owner HUNAN XINHUI PHARMA
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