A kind of method for preparing nitrile

Abstract

The invention provides a method for preparing nitrile. Aldoxime carboxylic ester is used as a reactant to prepare a nitrile compound. The aldoxime carboxylic ester can be completely converted into corresponding nitrile under common catalysis of ferric salt and phenol within a few minutes. The method for preparing the nitrile has the advantages of gentle reaction conditions, simple and easy-to-getused reagents, cheap and environment-friendly catalyst, wide substrate application range, simple operation, rapid reaction and the like.

Description

technical field [0001] The present invention relates to a process for the preparation of nitriles by the rapid conversion of aldoxime carboxylates to the corresponding nitriles using catalysts. Background technique [0002] Nitrile compounds are important chemical raw materials, which are widely used in the manufacture of medicines, synthetic fibers and plastics, and are also used in industries such as electroplating, steel quenching and mineral processing. Nitrile is also an important synthetic intermediate at the same time. It can complete the conversion to various functional groups such as carboxyl, ketone carbonyl, and amide through different reaction conditions. Cyclization generates heterocyclic compounds, etc. Therefore, the synthesis of cyanide has been valued by many researchers. Existing existing nitrile preparation method is a lot at present, and traditional synthesis method comprises Rosenmund reaction (reaction of halogenated arene and CuCN), Sandemann reactio...

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Problems solved by technology

Although the various methods mentioned above can synthesize nitriles, these methods all have some defects more or less, such as toxic cyanide, expensive and toxic noble metal catalysts, a large amount of dehydrating reagents, harsh reaction conditions, long reaction time, etc.

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