A microfluidic device, driving method and microfluidic detection system
A driving method and microfluidic technology, applied in fluid controllers, chemical instruments and methods, instruments, etc., can solve the problems of the disadvantages of precise measurement and control of droplets, and achieve the effect of precise measurement
Active Publication Date: 2020-04-21
BOE TECH GRP CO LTD
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Problems solved by technology
[0002] The microfluidic chip used in a typical microfluidic detection system generally does not include a detection system for the position, shape, flow velocity, contact angle and other properties of the liquid, and the control of the liquid in the microfluidic chip is completely dependent on the external microfluidic pump ( or other microfluidic drive systems), with the improvement of detection requirements in the field of biomedicine, the precise measurement and regulation of droplets in microfluidic chips has been slightly disadvantaged
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[0044] Existing microfluidic devices cannot detect flow parameters such as the position, shape, flow velocity, and contact angle of the liquid. The control of the liquid depends entirely on the external microflow pump (or other microfluidic drive system). With the increase in demand, microfluidic devices have shown a slight disadvantage in the precise measurement and regulation of liquids.
[0045] In order to solve the above technical problems, the present invention provides a microfluidic device, the microfluidic device includes a lower substrate and at least two waveguides arranged on the lower substrate, the waveguides are on the surface of the lower substrate A containment space is defined, which is capable of containing liquid. The liquid in the accommodating space is the liquid to be detected, generally a liquid drop, or a liquid column extending for a certain distance.
[0046] The waveguide includes a first waveguide, and the refractive index of the first waveguide i...
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Abstract
The invention relates to the field of sensing and biological detection, and discloses a microfluidic device, a driving method and a microfluidic detection system. The microfluidic device comprises at least two waveguides for defining a containing space on the surface of a substrate, the containing space is capable of containing a liquid, by setting at least one of the waveguides to have a refractive index greater than that of a medium surrounding the waveguide rate, forming an optical waveguide structure, so that light incident into the waveguide propagates in the waveguide in a manner of total reflection. However, when the accommodating space contains liquid, when the light in the waveguide propagates to the corresponding position of the liquid, total reflection no longer occurs, and part of the light enters the liquid. The light is emitted to the surroundings under the scattering effect of the liquid. By setting a plurality of optical detection structures on the surface of the substrate, the light emitted from the liquid can be detected. According to the above light, the parameters of the droplet can be measured more accurately, so that the micro The flow control detection system realizes higher requirements for regulation.
Description
technical field [0001] The invention relates to the technical field of sensing and biological detection, in particular to a microfluidic device, a driving method and a microfluidic detection system. Background technique [0002] The microfluidic chip used in a typical microfluidic detection system generally does not include a detection system for the position, shape, flow velocity, contact angle and other properties of the liquid, and the control of the liquid in the microfluidic chip is completely dependent on the external microfluidic pump ( Or other microfluidic drive systems), with the improvement of detection requirements in the field of biomedicine, the precise measurement and regulation of droplets in microfluidic chips has been slightly disadvantaged. Contents of the invention [0003] The invention provides a microfluidic device, a driving method and a microfluidic detection system, which are used to measure droplet parameters more accurately. [0004] In order t...
Claims
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IPC IPC(8): G01N21/01B01L3/00
CPCB01L3/502715B01L2300/0654B01L2300/0645B01L2400/0427B01L3/502792B01L2200/0689B01L2400/0415B01L2400/0478G01N21/47G01N21/552
Inventor 王维孟宪芹孟宪东谭纪风梁蓬霞高健王方舟陈小川
Owner BOE TECH GRP CO LTD