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Pharmaceutical composition for treating allergic dermatitis and preparation thereof

A technology for allergic dermatitis and composition, which is applied in the field of pharmaceutical composition and preparations for treating allergic dermatitis, can solve problems such as allergic dermatitis that have not been found, and achieve the goal of reducing the number of administrations, relieving itching, and maintaining blood drug concentration Effect

Active Publication Date: 2019-05-28
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It has a wide range of biological activities, such as anti-cancer, lowering blood sugar, lowering blood pressure, enhancing the body's immune function, protecting the liver, anti-inflammation,

Method used

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  • Pharmaceutical composition for treating allergic dermatitis and preparation thereof
  • Pharmaceutical composition for treating allergic dermatitis and preparation thereof
  • Pharmaceutical composition for treating allergic dermatitis and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: a kind of tablet for the treatment of atopic dermatitis

[0047] 7 parts of catalpol, 40 parts of microcrystalline cellulose, 10 parts of lactose, 8 parts of sodium carboxymethylcellulose, 4 parts of crospovidone, and 0.5 part of magnesium stearate were prepared according to the following method:

[0048] (1) material preparation: take each raw material according to the formula quantity, pulverize catalpol through 40 mesh sieves, and obtain catalpol powder for subsequent use;

[0049](2) Tablet compression: mix the catalpol powder obtained in step (1) with microcrystalline cellulose, lactose, carboxymethyl cellulose and crospovidone evenly, then wet granulate, pass through a 12-mesh sieve for granulation, add hard After the magnesium fatty acid is mixed evenly, the tablet is pressed to obtain the tablet for treating atopic dermatitis of the present invention.

Embodiment 2

[0050] Embodiment 2: a kind of tablet for the treatment of atopic dermatitis

[0051] 5 parts of catalpol, 4 parts of fexofenadine hydrochloride, 50 parts of microcrystalline cellulose, 15 parts of lactose, 10 parts of sodium carboxymethyl cellulose, 5 parts of crospovidone, 0.5 parts of magnesium stearate, according to The method of Example 1 prepares the tablet for treating allergic dermatitis of the present invention.

Embodiment 3

[0052] Embodiment 3: A kind of capsule for the treatment of allergic dermatitis

[0053] 5 parts of catalpol, 4 parts of fexofenadine hydrochloride, 50 parts of microcrystalline cellulose, 15 parts of lactose, 10 parts of sodium carboxymethyl cellulose, 5 parts of crospovidone, 0.5 parts of magnesium stearate, according to Prepared as follows:

[0054] (1) Raw material preparation: take each raw material according to the formula quantity, pulverize catalpol and fexofenadine hydrochloride respectively through a 40-mesh sieve, mix uniformly to obtain mixed powder, and set aside;

[0055] (2) Granulation and filling: mix the mixed powder obtained in step (1) with microcrystalline cellulose, lactose, carboxymethyl cellulose and crospovidone, then wet granulate, pass through a 12-mesh sieve for granulation, Add magnesium stearate and mix evenly, fill in gelatin capsule shell, obtain the tablet of the present invention for treating atopic dermatitis.

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PUM

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Abstract

The invention relates to pharmaceutical composition for treating allergic dermatitis and a preparation thereof. The pharmaceutical composition for treating the allergic dermatitis is prepared from iridoid compound and optional antihistamine compound which is used as an active ingredient. The pharmaceutical composition can effectively relieve varieties of symptoms such as itching and the like of the allergic dermatitis. As the irridoid and the antihistamine are jointly used, not only is an allergic dermatitis treating effect more excellent, but also the application dosage of the antihistamine is reduced, and side effects are reduced. After the pharmaceutical composition is prepared into a sustained release preparation, drug administration times of medicine can be further reduced, the stableblood concentration can be maintained, and the side effects of the medicine can be further reduced; thus, the effect and safe pharmaceutical composition for treating the allergic dermatitis is provided.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a pharmaceutical composition for treating allergic dermatitis and a preparation thereof. Background technique [0002] Allergic dermatitis refers to a class of diseases that cause allergic reactions on the skin due to contact with allergens. It belongs to type I allergy and is mainly mediated by IgE. The etiology of allergic dermatitis may be related to factors such as infection, food or drugs. According to different etiologies, allergic dermatitis includes different types such as contact dermatitis, neurodermatitis, solar dermatitis, seborrheic dermatitis, and hormone-dependent dermatitis. The patient's skin showed symptoms such as redness, itching, shedding, and wheals, which seriously affected the patient's life. Although the ideal treatment plan for atopic dermatitis is to remove allergens, restore the patient's immune system, take symptomatic treatment for the symptoms ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P17/00A61P37/08
Inventor 黄瑞雷金慧鹏教传华张志勇赵丹刘洋
Owner MUDANJIANG MEDICAL UNIV