Composite artificial cornea and preparation method thereof

A kind of artificial cornea and composite technology, applied in the field of biomedical engineering, can solve the problems of artificial cornea that cannot be healed, the process is complicated, and the joint strength is not enough, and it is beneficial to surgical suture, with good biocompatibility and high tensile strength. high effect

Inactive Publication Date: 2019-05-31
广州锐澄医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biggest problem is: the front and rear membranes of the postoperative lens column affect vision, and the artificial cornea cannot heal with the patient's cornea, resulting in complications such as artificial cornea prolapse, joint edge water leakage, and intraocular infection.
However, this kind of artificial cornea is composed of three parts, the process is complicated, the tissue structure is complicated, and the materials lack sufficient bonding effect, which may easily cause the problem of dissociation of the implanted material or difficulty in healing with the recipient tissue. In particular, the strength of the junction is not enough

Method used

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  • Composite artificial cornea and preparation method thereof

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preparation example Construction

[0044] now refer to figure 1 , which shows a composite artificial cornea constructed and operated according to a specific embodiment, which includes a central optic zone made of a polymer and a corneal annular zone made of acellular matrix, wherein, in the central optic zone and the corneal annular zone The transition zone forms an interpenetrating network. The preparation method of above-mentioned composite artificial cornea comprises the following steps:

[0045] (1) Putting the acellular matrix material into a designated area in a mold of a specific size, placing the upper and lower molds, and applying appropriate pressure to obtain an artificial corneal stent;

[0046] (2) punch a central hole with a diameter of 2-8mm according to the design requirements in the central part of the artificial corneal stent prepared in step (1), and place it in the cornea forming mold, and drop the solution for preparing the central optical zone in the central hole, Closing the mold and ut...

Embodiment 1

[0055] A preparation method of a composite artificial cornea, comprising the following steps:

[0056] (1) Put the freeze-dried acellular matrix material into a designated area in a circular mold with a diameter of 9 mm, place the upper and lower molds, and apply pressure to obtain an artificial corneal stent;

[0057] (2) The central part of the artificial corneal stent prepared in step (1) is drilled a central hole with a diameter of 7mm according to the design requirements, and placed in the cornea forming mold, and the polymethacrylic acid 2-hydroxyethyl ether is added dropwise in the central hole The ester solution, the mold is closed, and the polymerization reaction of 2-hydroxyethyl methacrylate monomer with water and initiator is used to form an interpenetrating network in the transition zone between the central optical zone and the corneal annular zone;

[0058] (3) The artificial cornea obtained in step (2) is fully soaked in deionized water for 96 hours to remove th...

Embodiment 2

[0062] A preparation method of a composite artificial cornea, comprising the following steps:

[0063] (1) Put the freeze-dried acellular matrix material into a designated area in a circular mold with a diameter of 9 mm, place the upper and lower molds, and apply pressure to obtain an artificial corneal stent;

[0064] (2) The central part of the artificial corneal stent prepared in step (1) is drilled a central hole with a diameter of 8 mm according to the design requirements, and placed in a cornea forming mold, and the solution for preparing polymethylacrylate is added dropwise in the central hole, and closed a mold, utilizing the polymerization reaction of methyl (meth)acrylate monomer with water and an initiator, so that the transition zone between the central optical zone and the corneal annular zone forms an interpenetrating network;

[0065] (3) The artificial cornea obtained in step (2) is fully soaked in deionized water for 48 hours to remove the residual monomer in ...

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Abstract

The invention relates to a composite artificial cornea. The composite artificial cornea comprises a central optical area prepared by a polymer and an annular cornea area prepared by an acellular matrix, wherein an interpenetrating network is formed in a transition area between the central optical area and the cornea annular area. The integrated composite artificial cornea is high in tensile strength and biocompatibility and is easily fused with tissue.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a composite artificial cornea and a preparation method thereof. Background technique [0002] Corneal transplantation is the only effective treatment for corneal blindness. At present, the commonly used generalized artificial corneas are mainly divided into two categories: narrow artificial corneas made of materials such as polymers and metals, and bioartificial corneas made of biological sources such as collagen and acellular matrix. The biggest advantage of the artificial cornea in the narrow sense is its good optical performance. Generally, the central part is made of optically transparent materials such as polymethyl methacrylate or quartz glass. The biggest problem is: the front and rear membranes of the postoperative mirror column affect vision, and the artificial cornea cannot heal with the patient's cornea, causing complications such as artificial cornea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/14
Inventor 王晓然梁丹镭王涛杨习锋曾晨光
Owner 广州锐澄医疗技术有限公司
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