Composite stent material preparation method, product and application method thereof

A technology of composite scaffold and application method, which is applied in the field of preparation of composite scaffold materials, can solve problems such as limiting the application of hydroxyapatite powder, failing to meet the repair mechanical strength, and lacking controllability of drug sustained release, so as to facilitate large-scale promotion, Improve the mechanical properties and stability of aqueous solution, the effect of controllable degradation rate

Inactive Publication Date: 2019-05-31
XINJIANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the single-component hydroxyapatite powder material is brittle and has poor toughness, which cannot meet the mechanical strength required for repair, and as a sustained-release drug-loading system for bone nodules, the single-material drug-loaded tissue-engineered bone scaff

Method used

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  • Composite stent material preparation method, product and application method thereof
  • Composite stent material preparation method, product and application method thereof
  • Composite stent material preparation method, product and application method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Weigh 1 g of silk fibroin powder extracted by high-pressure degumming and 4 g of polyvinyl alcohol powder, blend the silk fibroin powder and polyvinyl alcohol powder with 35 g of distilled water, stir evenly, heat to 99 ° C in a water bath, and keep warm It was fully dissolved for 1 hour to prepare a composite hydrogel, that is, a silk fibroin / polyvinyl alcohol composite hydrogel with a concentration of 12%. The composite hydrogel was placed at -24°C for 8 hours, then placed at room temperature at 20°C for 4 hours to thaw, repeated freezing-thawing 3 times, and then placed in a water bath at 80°C for 0.5 hours. Weighing 1.8g of hydroxyapatite powder and 1g of composite hydrogel were fully stirred to make them uniformly mixed to obtain a composite scaffold material, that is, a silk fibroin / polyvinyl alcohol / hydroxyapatite composite material was obtained.

[0038] 3D printing equipment is used to quantitatively print the composite scaffold material. The specifi...

Embodiment 2

[0039]Example 2: Weigh 1 g of silk fibroin powder extracted by high-pressure degumming and 4 g of polyvinyl alcohol powder, blend the silk fibroin powder and polyvinyl alcohol powder with 35 g of distilled water, stir evenly, heat to 99 ° C in a water bath, and keep warm It was fully dissolved for 1 hour to prepare a composite hydrogel, that is, a silk fibroin / polyvinyl alcohol composite hydrogel with a concentration of 12%. The composite hydrogel was placed at -24°C for 8 hours, then placed at room temperature at 20°C for 4 hours to thaw, repeated freezing-thawing 3 times, and then placed in a water bath at 80°C for 0.5 hours. Weighing 1.8g of hydroxyapatite powder and 1g of composite hydrogel were fully stirred to make them uniformly mixed to obtain a composite scaffold material, that is, a silk fibroin / polyvinyl alcohol / hydroxyapatite composite material was obtained.

[0040] 3D printing equipment is used to quantitatively print the composite scaffold material. The specific...

Embodiment 3

[0041] Example 3: Weigh 1 g of silk fibroin powder extracted by high-pressure degumming and 4 g of polyvinyl alcohol powder, blend the silk fibroin powder and polyvinyl alcohol powder with 35 g of distilled water, stir evenly, heat to 99 ° C in a water bath, and keep warm It was fully dissolved for 1 hour to prepare a composite hydrogel, that is, a silk fibroin / polyvinyl alcohol composite hydrogel with a concentration of 12%. Put the composite hydrogel at room temperature of 20°C for 36 hours; then weigh 1.8g of hydroxyapatite powder and 1g of composite hydrogel and mix them well to make a composite scaffold material, that is, Silk fibroin / polyvinyl alcohol / hydroxyapatite composite.

[0042] 3D printing equipment is used to quantitatively print the composite scaffold material. The specification is 10×10×10mm 3 The three-dimensional porous structure scaffold, the three-dimensional porous structure scaffold was placed under the condition of -24 ℃ for 48 hours to freeze-dry, and...

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Abstract

The invention discloses a composite stent material preparation method and a product and an application method thereof. The method includes mixing silk fibroin powder with polyvinyl alcohol powder anddistilled water, conducting repeated freezing on the mixture and then fully mixing the mixture with hydroxyapatite powder and then conducting freeze drying. The preparation method is simple in processstep and convenient to operate. A freeze drying physical method is reasonably matched to prepare the material, and the mechanical problem like brittleness of the single material is solved. The secondary conformation of the composite stent material is changed, the mechanical performance of the composite stent material and the water solution stability are improved, no chemical reagent is added in the whole process, and no toxic or side effects are generated. The composite stent material has high forming precision, good mechanical property, controllable degradation rate and stable drug release rate. A prepared three-dimensional porous structure stent has good pore penetration, meets the requirements of the drug-loading tissue engineering bone stent material for the porous structure, and is favorable for wide-scale promotion.

Description

technical field [0001] The invention belongs to the technical field of composite materials, and in particular relates to a preparation method of a composite support material, a composite support material product and an application method thereof. Background technique [0002] The use of drug-loaded tissue-engineered bone scaffolds is of great significance for the treatment of bone tuberculosis patients and the repair of bone defects. Appropriate methods are used to load the drug on the stent and implant it into a specific part of the body, and the quantitative and uniform release of the drug is controlled through the interaction between the stent and the drug. The drug-loaded sustained-release composite material plays a vital role in the mechanical properties, biocompatibility, degradation performance and controlled release of drugs of the stent. In order to make drug-loaded tissue-engineered bone scaffolds meet the topological structure required for bone defects, effective...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/16A61L27/12A61L27/50A61L27/56A61L27/58B33Y10/00B33Y70/00
Inventor 许燕张旭婧周建平徐国强海几哲陈慧明
Owner XINJIANG UNIVERSITY
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