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Application of quantitative detection of USP10 protein in prognosis kit of primary liver cancer

A primary liver cancer and prognosis judgment technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of lack of molecular markers for disease monitoring and prognosis judgment

Active Publication Date: 2019-06-11
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there is still a lack of effective disease monitoring and prognostic molecular markers after liver cancer surgery. At present, there is an urgent need for a marker that can predict the recurrence risk and prognosis of patients after surgery.

Method used

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  • Application of quantitative detection of USP10 protein in prognosis kit of primary liver cancer
  • Application of quantitative detection of USP10 protein in prognosis kit of primary liver cancer
  • Application of quantitative detection of USP10 protein in prognosis kit of primary liver cancer

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Embodiment Construction

[0049] The embodiments of the present invention will be described in detail below with reference to examples. The immunohistochemical method described in this protocol can quantitatively detect USP10, which can be understood by those skilled in the art. If the specific conditions are not indicated in the implementation plan, it shall be carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional reagents or instruments.

[0050] The Kaplan-Meier method in the survival analysis module of SPSS software adopts the Kaplan-Meier method in the survival time relation of protein expression level and hepatocellular carcinoma patient among the present invention to analyze, in accompanying drawing, represent with OS (overall survival period), DFS (disease-free survival period) .

[0051] Retrospective study: Paraffin samples from 74 cases of h...

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Abstract

The invention belongs to the field of molecular biology and clinical prognosis, and relates to an application of a USP10 protein expression level in the prognosis of the primary liver cancer. Specifically, the invention relates to an application of quantitative detection of USP10 protein in the prognosis of the primary liver cancer, the preparation of a prognosis kit of the primary liver cancer, and a method for detecting the USP10 protein expression level in a primary liver cancer tissue. The relative expression of USP10 protein and a recurrent risk and prognosis of a primary liver cancer patient are clearly obtained by detecting the relative expression of the USP10 protein in the primary liver cancer tissue and combining lifetime follow-up visit. The low expression of the USP10 protein indicates a high recurrent risk and poor prognosis of the primary liver cancer, and the application has a good clinical application prospect in the postoperative monitoring and prognosis.

Description

technical field [0001] The invention belongs to the fields of molecular biology and clinical prognosis judgment, and specifically relates to the application of quantitative detection of USP10 protein in the preparation of primary liver cancer prognosis judgment, primary liver cancer prognosis judgment kit, and detection of USP10 protein expression in primary liver cancer tissue horizontal approach. Background technique [0002] Liver cancer is one of the malignant tumors with the highest mortality rate. As of 2013, the World Health Organization announced that primary liver cancer caused 745,517 deaths worldwide, and about 383,000 people died of liver cancer every year in my country, accounting for 51% of the global liver cancer deaths. [0003] In recent years, with the advancement of diagnosis and treatment methods, the comprehensive application of surgery, intervention, radiotherapy, chemotherapy, and biological targeted therapy has improved the prognosis of patients with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
Inventor 许国旺宁振卢畅朴海龙
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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