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Cancer prevention and treatment glucosan and yeast cell wall extract for oral administration

A technology of yeast cell wall and glucan, which is applied in the field of medicine and health care to achieve the effect of repairing human immunity

Inactive Publication Date: 2019-06-14
石雨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, a large number of studies are using β-1,3 / 1,6-glucan combined with monoclonal antibodies and other anti-cancer components to form compositions for anti-cancer, using β-1,3 / 1,6-glucan The characteristics of the components of glycans also recognize that there are various structures of β-1,3 / 1,6-glucan, but the relationship between the specific structure of β-1,3 / 1,6-glucan and the anticancer effect relationship has not yet been reported

Method used

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  • Cancer prevention and treatment glucosan and yeast cell wall extract for oral administration
  • Cancer prevention and treatment glucosan and yeast cell wall extract for oral administration
  • Cancer prevention and treatment glucosan and yeast cell wall extract for oral administration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A yeast cell wall extract, the preparation method of which is:

[0044] 1) Using a conventional method to break the yeast cell wall and remove the cell content to obtain the yeast cell wall;

[0045] 2) Add 2-5% sodium hydroxide solution to the yeast cell wall, disperse, react at a temperature range of 70-90°C for 45 minutes to 3 hours, and remove the supernatant after centrifugation;

[0046] 3) Repeat step 2) 3 to 5 times;

[0047] 4) Titrate the pH of the product in step 3) to a range of 4.0 to 5.0 with a strong acid, redisperse in a sodium hydroxide solution, react at 70° C. for 45 minutes, and centrifuge to obtain a solid component.

[0048] 5) Washing and purifying with distilled water, and drying to obtain yeast cell wall extract powder, the purity of dextran is 81.46% as detected by high performance liquid chromatography.

[0049] The obtained yeast cell wall extract is displayed by a 9500-fold electron microscope as shown in the figure figure 2 As shown, th...

Embodiment 2

[0052] A yeast cell wall extract, the preparation method of which is:

[0053] 1) Using a conventional method to break the yeast cell wall and remove the cell content to obtain the yeast cell wall;

[0054] 2) Add 2-5% sodium hydroxide solution to the yeast cell wall, disperse, react at a temperature range of 70-90°C for 45 minutes to 3 hours, and remove the supernatant after centrifugation;

[0055] 3) Repeat step 2) 5 to 10 times;

[0056] 4) Titrate the pH of the product in step 3) to a range of 4.0 to 5.0 with a strong acid, redisperse in a sodium hydroxide solution, react at 70° C. for 45 minutes, and centrifuge to obtain a solid component.

[0057] 5) Washing and purifying with distilled water, and drying to obtain yeast cell wall extract powder, the purity of dextran is 93.54% as detected by high performance liquid chromatography.

[0058]The obtained yeast cell wall extract is displayed by a 9500-fold electron microscope as shown in the figure figure 2 As shown, th...

Embodiment 3

[0060] Purchase two commercially available β-1,3 / 1,6-glucans, and the β-1,3 / 1,6-glucans of Example 1 and Example 2 of the present invention, under a 9500X electron microscope Under the observation, the image results are as follows image 3 As shown, its function is shown in the following table:

[0061] Table 1 Molecular structure and anticancer effect contrast of dextran of the present invention and commercially available dextran

[0062]

[0063]

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PUM

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Abstract

The invention relates to cancer prevention and treatment glucosan and a yeast cell wall extract for oral administration. The cancer prevention and treatment functional ingredients of the glucosan arebeta-1,3-1,6-glucosan units with specific branch structures; the glucosan is obtained in a mode of orally taking the yeast cell wall extract; the yeast cell wall extract contains 75 to 95 percent of beta-1,3-1,6-glucosan; the glucosan branch chains are of long branch chain structures; the content of the branch chain glucosan accounts for 18 percent or higher of the total quantity of the glucosan;when the glucosan is used for preventing and treating the cancer; the oral administration dose every day is 0.01 to 0.2 g / kg body weight; the duration is at least 10 months. The invention provides theglucosan structure with exact and stable anticancer effects; the yeast cell wall extract capable of being orally taken and capable of being finally absorbed through intestinal tracts to obtain the beta-1,3-1,6-glucosan branch unit is provided. When the glucosan is matched with conventional operation, radiotherapy and chemotherapy, a patient can obtain the treatment effect of recovering the carcino-embryonic antigen to the normal people level to the optimum degree.

Description

technical field [0001] The invention relates to the field of medicine and health care, in particular to a glucan with the effect of preventing and treating cancer and an oral yeast cell wall extract. Background technique [0002] Dextran refers to a homopolysaccharide composed of glucose as a monosaccharide, and the glucose units are connected by glycosidic bonds. With the different types of microorganisms and growth conditions, their structures are also different. Among the glucans, β-glucan is the most physiologically active. The active structure of β-glucan is a polysaccharide composed of glucose units, most of which are combined by β-1,3, which is the way of glucose chain connection. It can activate macrophages and neutrophils, etc., so it can increase the content of leukin, cytokinin and special antibodies, and fully stimulate the body's immune system. β-glucan can quickly restore the ability of lymphocytes in the injured body to produce cytokines (IL-1) to normal, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02A61K31/716A61K36/064A61K9/14A61P35/00A61P37/04
Inventor 石雨
Owner 石雨
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