A kind of coating method of traditional Chinese medicine pellet

A technology for traditional Chinese medicine and pellets, applied in the field of coating of traditional Chinese medicine pellets, can solve the problems of reducing the spraying speed of coating liquid, unstable physical and chemical properties, collapsed bed, etc.

Active Publication Date: 2021-09-07
SICHUAN JISHENGTANG PHARMLS
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most commonly used coating method is solvent coating method, including organic solvent coating and water solvent coating, but due to the use of organic solvents, it may cause solvent residues and affect the quality of medicines. Special requirements limit the application of organic solvent coating methods to a certain extent; compared with organic solvent coating, water solvent coating does not require the use of organic solvents, which reduces the quality risk caused by solvent residues, and also reduces Reduce the coating cost, and gradually become the mainstream choice of coating technology for traditional Chinese medicine pellets
[0004] The coating of traditional Chinese medicine pellets is usually carried out in a coating pan or a fluidized bed. However, since the extracts of traditional Chinese medicine preparations, especially traditional Chinese medicine compound preparations, are mostly extracts, liquid extracts or amorphous powders, these materials generally have a large Viscosity and hygroscopicity, unstable physical and chemical properties, problems such as stickiness, bed collapse, muzzle clogging, and low pelleting rate are prone to occur in the process of fluidized bed coating, which brings great difficulties to the coating of traditional Chinese medicine pellets. big difficulty
For example, the traditional Chinese medicine Acanthopanax spinosa extract pellets contain a large amount of saponins, flavonoids, polysaccharides and other components, which are relatively viscous. During the fluidized bed coating process, the coating failure is easily caused by problems such as stickiness and bed collapse.
At present, the method to solve the above problems is mainly to dilute the coating solution, reduce the spraying speed of the coating solution, or add a certain amount of anti-adhesive agent, such as ethanol, talcum powder, etc. in the coating solution, but the dilution of the coating solution is often It leads to the reduction of coating rate, which increases the production cost, and for some traditional Chinese medicine pellets with high viscosity, the ideal coating effect cannot be achieved. At the same time, the addition of excessive anti-adherent may lead to the release The performance of the drug changes, which adversely affects the quality of the drug

Method used

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  • A kind of coating method of traditional Chinese medicine pellet
  • A kind of coating method of traditional Chinese medicine pellet
  • A kind of coating method of traditional Chinese medicine pellet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Preparation of Acanthopanax acanthopanax extract: the medicinal material of Acanthopanax senticosus (collected from Yichun District, Yichun City, Heilongjiang Province, identified as Acanthopanax senticosus by Professor Song Liangke of Southwest Jiaotong University, Latin name: ACANTHOPANACIS SENTICOSI RADIX ETRHIZOMA SEU CAULIS) was pulverized into Granules, add 8 times the amount of 28% ethanol, heat to boiling, extract twice, each time for 1 hour, and combine the extracts; combine and concentrate under reduced pressure to a relative density of 1.18-1.20g / ml to obtain an extract; Dried extract powder, set aside.

[0074] Preparation of ball core: take an appropriate amount of cornstarch and pass through a 200-mesh sieve; weigh 2% (relative to the amount of cornstarch) hydroxypropyl methylcellulose E5 as a binder, add water to make a 1% binder solution Get a part of the starch and put it into a centrifugal granulator (Chongqing Yingge multifunctional centrifugal granul...

Embodiment 2

[0080] Preparation of Acanthopanax acanthopanax extract: the medicinal material of Acanthopanax senticosus (collected from Yichun District, Yichun City, Heilongjiang Province, identified as Acanthopanax senticosus by Professor Song Liangke of Southwest Jiaotong University, Latin name: ACANTHOPANACIS SENTICOSI RADIX ETRHIZOMA SEU CAULIS) was pulverized into Granules, add 8 times the amount of 30% ethanol, heat to boiling, extract twice, each time for 1 hour, and combine the extracts; combine and concentrate under reduced pressure to a relative density of 1.18-1.20g / ml to obtain an extract; Dried extract powder, set aside.

[0081] The preparation of ball core: take appropriate amount of lactose, sieve 200 orders; Take by weighing 3% (relative to the amount of lactose) hydroxypropyl methylcellulose E5 as binder, add water and be made into 1% binder solution; Take A part of lactose is put into the centrifugal granulator, and the binder is sprayed into the silo from the nozzle of ...

Embodiment 3

[0087] Preparation of Acanthopanax extract: take Acanthopanax medicinal material (collected from Tieli District, Yichun City, Heilongjiang Province, identified as Acanthopanax, a traditional Chinese medicine by Professor Song Liangke of Southwest Jiaotong University, Latin name: ACANTHOPANACIS SENTICOSI RADIX ETRHIZOMA SEU CAULIS), and Break it into 5mm particles, add 8 times the amount of deionized water, heat to 80°C, extract 4 times, each time for 1.5 hours, and combine the extracts; the combined solution is concentrated under reduced pressure to a relative density of 1.18-1.20g / ml to obtain an extract; The extract liquid is dried to obtain extract powder, which is set aside.

[0088] Preparation of pellet cores: use commercially available microcrystalline cellulose blank pellet cores (Asahi Kasei Co., Ltd., Japan), with a particle size of 750 μm-850 μm.

[0089] Preparation of Acanthopanax senticosus pellets: (1) Gradually add Acanthopanax senticosus extract extract powder...

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Abstract

The invention provides a coating method of traditional Chinese medicine pellets, which uses a pharmaceutically acceptable auxiliary material to coat a layer of powder layer on the surface of the pellets containing Chinese medicine extracts, and then uses fluidized bed coating technology for coating; the present invention The coating method of traditional Chinese medicine pellets can be used for the coating of various traditional Chinese medicine vegetarian pills, especially for pellets containing viscous traditional Chinese medicine extracts, which can significantly improve the occurrence of problems in the fluidized bed coating process of Chinese medicine extract pellets. It has the advantages of high pilling rate, good formability, simple operation, low production cost and high efficiency, and is suitable for industrial mass production applications.

Description

technical field [0001] The invention belongs to the field of medicine manufacture, and in particular relates to a coating method of traditional Chinese medicine pellets. Background technique [0002] Traditional Chinese medicine pellets refer to spherical or quasi-spherical preparations with a diameter between 0.5-1.5mm, generally no more than 2.5mm. They have technological advantages such as simple production process, good fluidity, beautiful appearance, and strong stability. It belongs to the multi-unit drug delivery system, which has many advantages compared with the single-dose drug delivery system; each dosage usually contains dozens or hundreds of pellets, and the drug release behavior is the sum of the individual pellets; in vivo The distribution area is large, the bioavailability is high, and the intestinal irritation is small; the residence time in the stomach is long, the particle size is small, and the transport is less affected by the rhythm of food delivery. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/32A61K47/02A61K36/254
Inventor 柯潇边俊杰
Owner SICHUAN JISHENGTANG PHARMLS
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