Method for measuring trace alkaloids and nitrosamines in cigarette filters

A determination method and cigarette filter technology, which are applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of complicated and time-consuming pretreatment, and achieve the effect of simplifying the sample pretreatment procedure, strong selectivity, and reducing the interference of impurities
CN109975447APending Publication Date: 2019-07-05CHINA TOBACCO GUIZHOU IND
7 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA TOBACCO GUIZHOU IND
Publication Date
2019-07-05

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a method for measuring trace alkaloids and nitrosamines in cigarette filters. The method includes the following steps that: a) smoked cigarette filters are acquired, and are longitudinally cut, the cut cigarette filters are added to an extraction solvent and a deuterated isotope internal standard, extraction is performed with an accelerated solvent extraction method, and anextract liquid is collected; b) the extract liquid is added into a QuECHERS kit and is subjected to vortex mixing for 1-3 minutes, and centrifuging is performed at the speed of 9000-11000 rpm for 3-7minutes, and a supernate can be obtained; and c) a UPLC-HR-MS method is adopted to perform quantitative analysis on trace alkaloids and specific nitrosamines for cigarettes in the supernate. With themethod disclosed by the invention adopted, 7 trace alkaloids, namely, nicotyrine, neonicotine, nornicotine, myosmine, cotinine, nicotelline and N-formyl nornicotine and four specific nitrosamines, namely NNN, NNK, NAT and NAB in the main stream smoke of the cigarettes can be measured simultaneously. The method has the advantages of high sensitivity, a high accuracy and high selectivity, and is suitable for the rapid determination of trace alkaloids and nitrosamines in batch cigarette filters.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of physical and chemical testing of chemical components of tobacco products, and in particular relates to a method for measuring trace alkaloids and nitrosamines in cigarette filters. Background technique

[0002] Tobacco trace alkaloids are one of the most important chemical components in tobacco and cigarette smoke. The content of trace alkaloids can affect the aroma, concentration and irritation of cigarettes. At the same time, tobacco trace alkaloids are also the source of tobacco-specific nitrosamines (TSNAs). precursor substances. The U.S. FDA has listed such as N-nitroso nornicotine (NNN), 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone (NNK), N-nitroso Four TSNAs including neonicotinoid (NAT) and N-nitrosobasine (NAB) were included in the list of harmful ingredients. During the smoking process of cigarettes, cigarette filters will retain some tobacco trace alkaloids and TSNAs. Accurate determination...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More