Gene sequence optimization method, device and data processing terminal

A data processing terminal and optimization method technology, which is applied in sequence analysis, bioinformatics, instruments, etc., can solve the problems of complex optimization, large amount of codon information, and low accuracy of optimization results, so as to simplify complexity and improve accuracy degree of effect

Active Publication Date: 2020-10-02
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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Problems solved by technology

However, due to the large amount of codon information, the optimization process is often complex and the accuracy of the optimization results is low.

Method used

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  • Gene sequence optimization method, device and data processing terminal
  • Gene sequence optimization method, device and data processing terminal
  • Gene sequence optimization method, device and data processing terminal

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Embodiment Construction

[0049] The following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all of them. The components of the embodiments of the application generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations.

[0050]Accordingly, the following detailed description of the embodiments of the application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but merely represents selected embodiments of the application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without making creative efforts belong to the scope of protection of the present application.

[0051] It...

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Abstract

The embodiment of the present application provides a gene sequence optimization method, device and data processing terminal, by obtaining the amino acid sequence corresponding to the codon sequence to be optimized, and importing the amino acid sequence into a pre-established optimization model for optimization to obtain the codon box sequence. Wherein, each group of codon boxes contained in the codon box sequence corresponds to at least one group of codons, and the codons corresponding to the same group of codon boxes contain the same code elements. Then for each codon box, obtain the codon corresponding to the codon box, and the codon corresponding to the amino acid corresponding to the codon box, obtain an optimized codon according to the codons corresponding to the two, and use the optimized codon Optimize the codon sequence to be optimized. In this way, by optimizing the way to obtain the codon box, the complexity of the optimization process is simplified, and the method of combining amino acids and codons corresponding to the codon box to obtain the optimized codon improves the accuracy of the optimized codon.

Description

technical field [0001] The present application relates to the technical field of biological information processing, in particular, to a gene sequence optimization method, device and data processing terminal. Background technique [0002] With the development of biotechnology, more and more fields use heterologous expression systems to generate recombinant proteins for the development of vaccines and pharmaceuticals. Codon is the basic principle of correspondence between the information carried by nucleic acid and the information carried by protein, and is the basic link of information transmission in organisms. After studying the codon usage bias of different species, people found that the genes of different species have obvious bias in codon usage. When the recombinant protein is expressed heterologously, the codon bias has a great influence on the expression level of the protein. Optimizing codons is the most critical factor in improving gene expression. In codon optimi...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B30/00
Inventor 符红光钟秀琴梁晏宾许阳黄磊
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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