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Preparation method of comfrey silicone oil and its composition preparation

A composition and silicone oil technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of inconvenient application, incomplete drug absorption, etc., achieve convenient carrying and use, improve bioavailability, and avoid inactivation. Effect

Active Publication Date: 2021-10-01
CHONGQING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The comfrey oil sold in the market is viscous due to the extraction of oil substances, which is inconvenient to apply and the drug absorption is not complete

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This example provides a spray with comfrey husk and simethicone as the main raw materials. Simethicone is used to extract the main components of comfrey husk, and a water-bath extraction method is used to obtain a comfrey silicone oil extract. After dilution and packaging operations, purple Grass silicone oil composition spray.

[0026] The components of the comfrey silicone oil composition spray include 2200 parts of comfrey bark and 17600 parts of simethicone oil, calculated by weight fraction. 17600 parts of comfrey silicone oil, 8340 parts of diluent, 440 parts of flavoring agent, calculated in parts by volume.

[0027] This embodiment provides a preparation method of comfrey silicone oil composition spray, comprising the following steps:

[0028] (1) Dissolve small pieces of shikonin in simethicone oil, soak them for a certain period of time in an orthogonal test design, and then extract them in a water bath, and optimize the best extraction process to prepare a s...

Embodiment 2

[0038] This example provides a spray with comfrey husk and simethicone as the main raw materials. Simethicone is used to extract the main components of comfrey husk, and a water-bath extraction method is used to obtain a comfrey silicone oil extract. After dilution and packaging operations, purple Grass silicone oil composition spray.

[0039] The components of the comfrey silicone oil composition spray include 2400 parts of comfrey bark and 19200 parts of simethicone oil, calculated by weight fraction. 19200 parts of comfrey silicone oil, 9099 parts of diluent, 479 parts of flavoring agent, calculated in parts by volume.

[0040] This embodiment provides a preparation method of comfrey silicone oil composition spray, comprising the following steps:

[0041] (1) Dissolve small pieces of shikonin in simethicone oil, soak them for a certain period of time in an orthogonal test design, and then extract them in a water bath, and optimize the best extraction process to prepare a s...

Embodiment 3

[0051] This example provides a spray that uses comfrey husk and simethicone as raw materials, uses simethicone to extract the main components of comfrey husk, obtains comfrey silicone oil extract by water bath extraction, and obtains comfrey through dilution and packaging operations Silicone oil composition spray.

[0052] The components of the comfrey silicone oil composition spray include 2700 parts of comfrey bark and 21600 parts of simethicone oil, calculated by weight fraction. 21600 parts of comfrey silicone oil, 10237 parts of diluent, 539 parts of flavoring agent, calculated in parts by volume.

[0053] This embodiment provides a preparation method of comfrey silicone oil composition spray, comprising the following steps:

[0054] (1) Dissolve small pieces of comfrey husk in simethicone oil, soak them for a certain period of time in an orthogonal experiment design, then extract them in a water bath, and optimize the best extraction process to prepare a solution to obt...

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PUM

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Abstract

The invention discloses the preparation method of the comfrey silicone oil and its composition preparation. The invention uses simethicone oil to extract levoshikonin from the comfrey as the active ingredient, and combines the active components of the comfrey and the silicone oil for moisturizing and clearing away heat. , antibacterial, anti-inflammatory and other effects, add appropriate amount of diluent, flavoring agent and emulsifier, etc., to prepare external preparations such as comfrey silicone oil composition spray or ointment. The comfrey silicone oil composition preparation prepared by the present invention is especially suitable for preventing and treating diaper rash (red buttocks), skin ulcers, eczema, etc. in infants and young children, and can also be used as household kitchen supplies to prevent and treat burns and scalds. It has good stability and is easy to carry and use. convenient.

Description

technical field [0001] The invention relates to the field of preparation of comfrey silicone oil and its composition preparation, specifically preparing the comfrey silicone oil composition as spray or ointment. Background technique [0002] Comfrey oil is an oily traditional Chinese medicine liniment for external use. It has strong heat-clearing, detoxifying, antibacterial and anti-inflammatory effects. Comfrey contains shikonin naphthoquinones with strong fat solubility, and the effective substances mainly include acetylshikoninone, shikoninone, isobutyrylshikoninone, β,β-dimethylacryloylshikoninone, β -Hydroxyisovalerylshikonone and other active ingredients can inhibit the hyperpermeability of capillaries, and have antagonistic effects on inflammatory exudation, edema, and proliferative inflammation, because it can promote the proliferation of granulation tissue and promote wound healing. It is clinically used in the treatment of Ⅰ-Ⅱ burns and eczema. Due to the importa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/30A61K47/34A61K9/12A61K9/06A61P17/00A61P17/02
CPCA61K9/0014A61K9/06A61K9/12A61K36/30A61K47/34A61P17/00A61P17/02
Inventor 杨善彬王晴晴余龙宋明邹小慧肖荣明
Owner CHONGQING NORMAL UNIVERSITY
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