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Validation of inferred anticancer pathways

A pathway and active technology, applied in the system field of predicting drug response, can solve the problems that have not been verified by clinical data

Active Publication Date: 2019-08-23
NANTBIOSCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it should be clear that these methods are probabilistic and have not been validated with real-world clinical data

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  • Validation of inferred anticancer pathways
  • Validation of inferred anticancer pathways

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Embodiment Construction

[0039] The present invention provides methods for validating the predicted drug sensitivity of cancer cells present in an individual subject. In particular, the present invention provides methods for validating predicted pathway activity of anticancer drug sensitive pathways in solid tumors of a subject. The method includes:

[0040] a) obtaining a tumor-related sample from the subject;

[0041] b) obtaining omics data from the tumor-associated sample obtained in (a);

[0042] c) applying the omics data obtained in (b) to a pathway analysis engine configured to generate in silico predicted tumor cell pathway activity to provide an effective treatment of the subject's tumor or multiple pharmacologically active anticancer compounds;

[0043] d) obtaining enriched viable tumor cells from the subject's blood, preferably prior to treatment with one or more pharmaceutically active anticancer compounds, and subjecting the enriched viable tumor cells to at least one known and (c) ...

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Abstract

The invention provides a method of validating a predicted pathway activity of a pathway in a solid tumor of a subject, with a digital computer, the method comprising : a) obtaining a tumor associatedsample from the subject; b) obtaining omics data from the tumor associated sample obtained in (a); c) applying the omics data obtained in (b) to a digital computer programmed with a pathway analysis engine configured to generate predicted tumor cell pathway activities in silico, to provide a prediction of one or more pharmaceutically active anticancer compounds effective for treating the subject'stumor; d) obtaining enriched viable tumor cells from the subject, and interrogating the enriched viable tumor cells with at least one pharmaceutically active compound known to interact with a pathwayelement of one or more of the pathways predicted by (c), to measure anticancer activity of the at least one pharmaceutically active compound with respect to the subject's enriched viable tumor cells.

Description

technical field [0001] The field of the invention is systems and methods for validating predicted drug responses based on genomic and / or omics information. Background technique [0002] The Background Description includes information useful in understanding the present invention. It is not an admission that any information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art. [0003] All publications and patent applications herein are incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. If the definition or usage of a term in an incorporated reference is inconsistent or contrary to the definition of the term provided herein, the definition of that term herein applies and the definition of that term in that reference does not apply. [0004] Various sys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B5/00G16B5/20
CPCG16B5/00G16B5/20G16H20/10G16B40/20
Inventor K·尼亚齐S·拉比扎黛斯N·J·维奇
Owner NANTBIOSCI