A shear force-responsive supramolecular biomimetic articular cartilage material with dynamic lubrication and self-healing ability and preparation method thereof

A dynamic lubrication, bionic joint technology, applied in tissue regeneration, pharmaceutical formulations, prostheses, etc., can solve the problems of loss of physiological lubrication function, damage of arched fiber network structure, increase of friction coefficient, etc.

Active Publication Date: 2021-11-05
JILIN UNIV
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Problems solved by technology

However, certain occupational labor, strenuous exercise, genu varus and valgus deformity, etc., cause local wear and tear on the entire joint, resulting in the destruction of the arched fiber network structure of the cartilage mechanism, increased friction coefficient, degeneration of cartilage and loss of original physiological lubrication. Function

Method used

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  • A shear force-responsive supramolecular biomimetic articular cartilage material with dynamic lubrication and self-healing ability and preparation method thereof
  • A shear force-responsive supramolecular biomimetic articular cartilage material with dynamic lubrication and self-healing ability and preparation method thereof
  • A shear force-responsive supramolecular biomimetic articular cartilage material with dynamic lubrication and self-healing ability and preparation method thereof

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Effect test

Embodiment 1

[0019] Measure 50 mL of hydroxyethylacrylamide in a conical flask, then weigh 5 g of monomer polyvinyl alcohol powder and add it to the above solution, add crosslinking agent glutaraldehyde and initiator ketoglutaric acid to the solution, crosslink The final concentrations of the coupling agent and the initiator were both 0.5 μg / mL, and the solution was mixed evenly by magnetic stirring (800 r / min) for 50 min.

[0020] (2) Take 40 mL of the solution prepared in step (1), add 60 mg of fluorenylmethoxycarbonyl-L-tryptophan; magnetically stir at 85 °C for 3 h to dissolve the monomer; after dissolving, cool the solution to room temperature, A solution with a concentration of fluorenylmethoxycarbonyl-L-tryptophan of 1.5 mg / mL was obtained, and the above solution was exposed to ultraviolet light for 5 h to form a gel, and the surface of the sample was washed with deionized water to remove residual monomers, and the obtained hydrogel was the The shear force-responsive supramolecular ...

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Abstract

A shear force responsive supramolecular biomimetic articular cartilage material with dynamic lubricating and self-repairing ability and a preparation method thereof belong to the technical field of biomimetic self-repairing lubricating articular cartilage materials and its preparation. Inspired by articular cartilage, we organically combine covalently cross-linked high-strength hydrogel networks, shear-responsive supramolecular networks, and intrinsic self-repairing structural elements to propose a method for preparing articular cartilage-like active functions. The supramolecular smart hydrogel material itself has good mechanical properties and shear self-lubricating function; more importantly, the synergistic interaction of the material through the shear force-responsive exudation lubrication layer and the self-healing unit, in the simulation At the same time as the dynamic seepage lubrication mechanism, the double repair of the three-dimensional network structure and the shear force response self-lubrication function after material wear is realized. This design concept can be applied to the preparation of new artificial articular cartilage or self-repairing lubricating devices, and has broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of bionic self-repairing lubricating articular cartilage material and its preparation, in particular to a shear force responsive supramolecular bionic articular cartilage material with dynamic lubricating self-repairing ability and a preparation method thereof. Background technique [0002] Articular cartilage has a fiber network structure that bears mechanical loads and a natural dynamic lubrication function, which can make joints move flexibly under certain pressure conditions to meet the needs of normal physiological activities of people. Exudative lubrication is a classic articular cartilage lubrication mechanism, that is, when the cartilage is subjected to a normal load, the lubricating matrix in the cartilage seeps out to the surface of the cartilage to form a lubricating layer. Under the action of horizontal friction (shear force), this A lubricating layer will achieve super lubricating effect. We ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/18A61L27/50A61L27/52C08F261/04C08F220/58C08F220/56C08F265/04C08F220/54C08F220/18C08F222/38
CPCA61L27/16A61L27/18A61L27/50A61L27/52A61L2400/10A61L2430/06A61L2430/24C08F220/18C08F220/58C08F261/04C08F265/04C08F220/1818C08F220/56C08F220/54C08F222/385
Inventor 宋文龙张雪巍
Owner JILIN UNIV
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