Wetting anisotropic mesh screen and preparation method and application thereof

Abstract

The invention discloses a mesh screen with an anisotropic surface wetting behavior and a preparation method. The mesh screen has different hydrophilic properties in the depth direction; and after themesh screen is modified through plasma from the outside to the inside, the surface of the side facing plasma processing has strong hydrophilicity, the side back on to plasma processing has weak hydrophilicity, and therefore the mesh screen has a hydrophilicity gradient. The invention further discloses application of the mesh screen. The mesh screen is used for preparing reagent strips capable of testing biochemical and immune indexes simultaneously. According to the mesh screen, a multilayer grid stereo permeation structure for anisotropic wetting is adopted, and the mesh screen makes direct contact with the surface of liquid and has strong hydrophilicity, so that samples are rapidly spread out; as a solution gradually permeates into the bottom, the weaker the capillary phenomenon of a material, the stronger the hydrophobicity, and permeation migration is delayed; and in this way, it is ensured that the samples can be sufficiently spread to a large enough area in a sampling region, then the samples are uniformly apportioned to all detection regions, and methodological integration, detection and application of multiple items and multiple types are realized.

Description

technical field [0001] The invention relates to a mesh screen with anisotropic surface wetting behavior and a preparation method. The invention also relates to the application of the mesh screen for preparing reagent strips for simultaneous testing of biochemical and immune indexes. Background technique [0002] The conclusion of the clinical diagnosis needs to be judged by referring to the results of the two sets of biochemical and immune test indicators. Since the two rely on different methodologies, they correspond to different detection platforms, resulting in high cost, time-consuming, and cumbersome operations. Although the automated process can solve this key problem, it increases the cost and takes up space, so it tends to be promoted in large tertiary hospitals, but it is not suitable for small and medium hospitals and community clinics. The latter is the main application site of the popular Point-of-Care Testing (POCT), and what is more required is the combined us...

AI Technical Summary

Problems solved by technology

However, the wetting effect of ordinary mesh screens on biological samples is single: on the one hand, the hydrophilicity of the mesh screen is very strong, and the droplets on it have not had time to spread to the target area, and they have already begun to infiltrate rapidly; on the other hand, The hydrophobicity of the mesh screen is too strong, the surface tension of the droplet becomes larger, and it cannot effectively wet the interface and spread out

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