Application of miR-132 in preparation of drugs for addiction treatment

A 1.mir-132, drug technology, applied in the field of molecular biology and medicine, can solve problems such as normal biological influence amplification

Inactive Publication Date: 2019-09-06
SHENZHEN KANGNING HOSPITAL SHENZHEN MENTAL HEALTH INST SHENZHEN MENTAL HEALTH CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Normal biological effects of DA ar

Method used

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  • Application of miR-132 in preparation of drugs for addiction treatment
  • Application of miR-132 in preparation of drugs for addiction treatment
  • Application of miR-132 in preparation of drugs for addiction treatment

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Embodiment Construction

[0033] The principles and features of the present invention are described below in conjunction with the accompanying drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention. Definition of nouns:

[0034] 1) miRNA enhancer: a nucleic acid substance that increases the amount of corresponding miRNA in cells, such as miRNA mimics, strong promoter-driven miRNA expression vectors, etc.

[0035] 2) miRNA weakening substances: nucleic acid substances that reduce the amount of corresponding miRNA in cells, such as miRNA inhibitors, miRNA-sponge, etc.

[0036] 3) miRNA-sponge: a single-stranded RNA with multiple tandem repeats, each repeating unit has a complementary sequence to all or part of the corresponding miRNA sequence, so it can bind and absorb the corresponding miRNA, reducing the effective concentration of the miRNA in the cell .

[0037] 1. Research on SLC6A3 mRNA 3'UTR

[0038] We ca...

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Abstract

The invention relates to non-therapeutic application of miR-132 in regulating DAT (dopamine active transporter) gene expression in cells and also relates to a non-therapeutic application to regulate DAT gene expression in cells. The non-therapeutic method includes increasing or decreasing quantity of miR-132 in cells. The invention also relates to application of miR-132, miR-132 reinforcer or miR-132 weakener in the preparation of drugs to regulate cellular intake of dopamine, and also relates to application of miR-132, miR-132 reinforcer or miR-132 weakener in the preparation of drugs to treat psychoactive drug substances.

Description

technical field [0001] The invention relates to the fields of molecular biology and medicine. More particularly, it relates to the use of miR-132 in the preparation of medicaments for the treatment of addiction to psychoactive substances. Background technique [0002] Psychoactive substance addiction is a disorder of brain function caused by the use of psychoactive substances that makes it impossible for a person to control their use. Addiction to psychoactive substances is a chronic relapsing disorder usually accompanied by additional psychological or physical symptoms, typically symptoms such as involuntary drug use and withdrawal syndrome. [0003] The neurotransmitter dopamine (DA) controls a variety of functions, including motor, cognition, emotion and reward. A large amount of neuropharmacological evidence in humans and animals shows that the DA system plays an important role in the three stages of the addiction cycle (euphoria, withdrawal, and craving). It is a nor...

Claims

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Application Information

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IPC IPC(8): A61K31/7105A61P25/30A61P25/36
CPCA61K31/7105A61P25/30A61P25/36
Inventor 贾晓健荣晗杨梅刘慧铭刘铁榜
Owner SHENZHEN KANGNING HOSPITAL SHENZHEN MENTAL HEALTH INST SHENZHEN MENTAL HEALTH CENT
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