Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes

一种增强免疫、神经疾病的技术，应用在神经系统疾病、过敏性疾病、药物组合等方向，达到提高免疫增强功效的效果

Active Publication Date: 2019-09-13
COSMAX NS INC
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies are being actively conducted to reveal the immune-enhancing effect through these macrophages or to prevent, treat, or improve degenerative neurological diseases, but there are no studies on this symptom, using goji berries, mulberries, and jujubes as raw materials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes
  • Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes
  • Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Prepare a mixture of about 40 g of wolfberry (origin: China), about 40 g of mulberry (origin: Pakistan), and about 20 g of jujube (origin: Korea). After mixing 10 (v / w) times of water in the prepared mixture, reflux extraction at 95° C. for 4 hours, filtered under reduced pressure, and concentrated using a rotary vacuum concentrator to prepare a mixed extract. Afterwards, it was freeze-dried at -40°C for 72 hours.

Embodiment 2

[0093] Prepare a mixture of about 40 g of wolfberry (origin: China), about 40 g of mulberry (origin: Pakistan), and about 20 g of jujube (origin: Korea). After mixing 10 (v / w) times of water in the prepared mixture, reflux extraction at 95° C. for 4 hours, filtered under reduced pressure, and concentrated using a rotary vacuum concentrator to prepare a mixed extract. Afterwards, 50% by weight of dextrin was mixed and spray-dried.

experiment example 1

[0100] Experimental Example 1: Evaluation of Cytotoxicity

[0101] In order to evaluate the cytotoxicity of the compositions prepared in Examples 1-2 and Comparative Examples 1-3, cell viability was measured.

[0102] First, using RPMI 1640 medium containing penicillin (100 IU / mL), streptomycin (100 μg / mL) and 10% FBS, mice were placed in a 100 mm cell culture dish. The macrophage cell line RAW264.7 was grown to a density of 70-80%.

[0103] Afterwards, using MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide, 3-[4,5-dimethylthiazol-2- yl]-2,5-diphenyltetrazolium bromide) analysis (MTT assay). Adjust the density of the cultured mouse macrophage cell line RAW264.7 cells to 1 × 10 using RPMI 1640 medium 6After cell / mL, inoculated into 96-well plate (well plate), in 5% CO 2 and incubated at 37°C for 18 hours. After that, the medium was removed, and the test substance was incubated by using a medium containing the concentration prepared in each figure. A...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to a composition for enhancing immunity or a composition for preventing or alleviating neurodegenerative diseases, both of which contain, as an active ingredient, a mixture extract of goji berries, mulberries and jujubes or an extract mixture thereof.

Description

technical field [0001] The invention relates to a composition for enhancing immunity and a composition for preventing or treating degenerative neurological diseases, which comprises a mixed extract or an extraction mixture of wolfberry, mulberry and jujube. Background technique [0002] Macrophage, as a cell that secretes various substances in the process of phagocytosis and elimination of bacteria or foreign substances to regulate immune phenomena, plays a central role in the immune response to antigens, and is related to antigen presentation and non-specific immunity of lymphocytes In response, it exhibits direct damaging activity against tumor cells. In addition, it is known that the reactive substances (LPS or natural products) of Toll-like receptors (toll like receptors, TLRs) activate macrophages to produce proteins such as IL-1, IL-6, IL-10, IL-12 and TNF-α. Cytokines that regulate the proliferation of T and B cells, the activation of phagocytic macrophages, and prot...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K36/605A61K36/725A23L33/105A61P37/00A61P25/00
CPCA23L33/105A23V2002/00A23V2200/322A23V2200/324A61K36/605A61K36/725A61K36/815A61P25/00A61P37/00A61K2236/00A61K2300/00A61K2236/51
Inventor 白洸守金贤枝崔水英金镇学沈载锡朴泳珉金庠佑尹晩锡李胤钟
Owner COSMAX NS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap