Application of heterophyllin B in improving memory and/or preventing Alzheimer's disease
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An Alzheimer's, memory-improving technology
Active Publication Date: 2019-09-17
GUANGDONG OCEAN UNIVERSITY
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(2) Tau protein is the microtubule-associated protein with the highest content. After hyperphosphorylation, it will cause the loss of function of the cell vascular system, destroy the microtubule structure of neurons, cause brain neurodegeneration, and lead to Alzheimer's disease
Pseudostellariae peptides can play an immunomodulatory role by activating Ca2+/CaN/NFATc1/IF
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Embodiment 1
[0033] The preparation of embodiment 1 Radix Pseudostellariae water extract
[0034] Pseudostellaria Pseudostellariae (produced in Fujian Province) dried root tuber 30g, add 3L water to extract once, keep slightly boiling state for 1 hour, filter, the filtrate is freeze-dried to obtain water extract 7.2g, the yield is 24%.
Embodiment 2
[0035] Example 2 Preparation of Pseudostellaria cyclic peptide extract by organic solvent extraction
[0036] Pseudostellaria Pseudostellariae (produced in Fujian Province) dried root tuber 30g, add 3L 95% ethanol to extract once, keep slightly boiling state for 1 hour, filter, the filtrate is dried under reduced pressure to obtain alcohol extract. Resuspend the alcohol extract in 400mL petroleum ether, stir and dissolve twice at room temperature, discard the petroleum ether solution, add 400mL ethyl acetate to dissolve and extract twice, combine the filtrates, and dry under reduced pressure to obtain 200mg of total cyclic peptide extract, containing Pseudostellaria cyclic peptide B about 10mg.
Embodiment 3
[0037] Example 3 Preparation of Pseudostellaria cyclic peptide extract by macroporous resin method
[0038] Pseudostellaria Pseudostellariae (produced in Fujian Province) dried root tuber 30g, add 3L 95% ethanol to extract once, keep slightly boiling state for 1 hour, filter, the filtrate is dried under reduced pressure to obtain alcohol extract. Enriched with a macroporous adsorption resin column, gradient eluted with water, 40% ethanol, 65% ethanol, and 90% ethanol respectively, collected the 65% ethanol eluate, recovered ethanol under reduced pressure, and obtained 235 mg of total cyclic peptide extract, containing Prince Edward Circadin B is about 12mg.
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Abstract
The invention discloses application of heterophyllin B in improving memory and/or preventing the Alzheimer's disease, particularly discloses the memory enhancement function of a radix pseudostellariae aqueous extract, radix pseudostellariae cyclopeptide extract and heterophyllin B for normal mice and the amelioration function on learning and memory dysfunction of dementia mice by injecting Abeta1-42 to the paracele, and discusses the action mechanism of the heterophyllin B. Results show that the radix pseudostellariae aqueous extract, the radix pseudostellariae cyclopeptide extract and the heterophyllin B can significantly enhance the cognitive memory ability of the normal mice and ameliorate the memory impairment of the dementia model mice, the regeneration of cerebral cortex neurites is promoted, and cortical neuron loss and neurite atrophy which are induced by Abeta are prevented; results prompt that the heterophyllin B, a radix pseudostellariae solution and a cyclopeptide extract may reconstruct the neural circuit network by promoting the regeneration of the neurites to play the memory improvement role, and the heterophyllin B can be used for preparing drugs or health foods for preventing and treating the Alzheimer's disease.
Description
technical field [0001] The present invention relates to the technical field of biomedicine, and more specifically, relates to the application of heterophyllin B in improving memory and / or preventing and treating senile dementia. Background technique [0002] Alzheimer's disease (AD) is a long-term progressive neurodegenerative disease, accounting for about 60% to 70% of the total number of dementia patients. The inhibitor rivastigmine and the NMDA receptor inhibitor memantine belong to symptomatic therapy, which are not enough to improve the memory function of patients and are accompanied by serious side effects. The number of dementia patients in China ranks first in the world. According to reports, the number of dementia patients in China is expected to reach 14.1 million in 2020 and 23.3 million in 2030, bringing huge economic and nursing burdens to families and society. [0003] The pathogenesis of Alzheimer's disease has not yet been clarified. However, there are many...
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