Application of heterophyllin B in improving memory and/or preventing Alzheimer's disease

Abstract

The invention discloses application of heterophyllin B in improving memory and / or preventing the Alzheimer's disease, particularly discloses the memory enhancement function of a radix pseudostellariae aqueous extract, radix pseudostellariae cyclopeptide extract and heterophyllin B for normal mice and the amelioration function on learning and memory dysfunction of dementia mice by injecting Abeta1-42 to the paracele, and discusses the action mechanism of the heterophyllin B. Results show that the radix pseudostellariae aqueous extract, the radix pseudostellariae cyclopeptide extract and the heterophyllin B can significantly enhance the cognitive memory ability of the normal mice and ameliorate the memory impairment of the dementia model mice, the regeneration of cerebral cortex neurites is promoted, and cortical neuron loss and neurite atrophy which are induced by Abeta are prevented; results prompt that the heterophyllin B, a radix pseudostellariae solution and a cyclopeptide extract may reconstruct the neural circuit network by promoting the regeneration of the neurites to play the memory improvement role, and the heterophyllin B can be used for preparing drugs or health foods for preventing and treating the Alzheimer's disease.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, and more specifically, relates to the application of heterophyllin B in improving memory and / or preventing and treating senile dementia. Background technique [0002] Alzheimer's disease (AD) is a long-term progressive neurodegenerative disease, accounting for about 60% to 70% of the total number of dementia patients. The inhibitor rivastigmine and the NMDA receptor inhibitor memantine belong to symptomatic therapy, which are not enough to improve the memory function of patients and are accompanied by serious side effects. The number of dementia patients in China ranks first in the world. According to reports, the number of dementia patients in China is expected to reach 14.1 million in 2020 and 23.3 million in 2030, bringing huge economic and nursing burdens to families and society. [0003] The pathogenesis of Alzheimer's disease has not yet been clarified. However, there are many...

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(2) Tau protein is the microtubule-associated protein with the highest content. After hyperphosphorylation, it will cause the loss of function of the cell vascular system, destroy the microtubule structure of neurons, cause brain neurodegeneration, and lead to Alzheimer's disease

Pseudostellariae peptides can play an immunomodulatory role by activating Ca2+ / CaN / NFATc1 / IFN-γ signaling pathway in splenic lymphocytes, and Pseudostellaria cyclic peptide B can improve LPS-induced macrophage RAW264 by inhibiting PI3K / Akt signaling pathway. 7 The role of inflammation and oxidative stress; but there is no report about the effect of Pseudostellaria Pseudostellariae extract, especially Pseudostellaria cyclic peptide extract on the nervous system

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