Preparation method of nanometer hydroxyapatite powder

A nano-hydroxyapatite, hydroxyapatite technology, applied in nanotechnology, chemical instruments and methods, phosphorus compounds and other directions, can solve the problem of uneven particle size distribution, large particle size of hydroxyapatite powder, easy to appear Agglomeration and other problems, to achieve the effect of inhibiting aggregation and growth, eliminating local inhomogeneity, and increasing nucleation density

Pending Publication Date: 2019-09-17
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the present invention aims to propose a method for preparing nano-hydroxyapatite powder to solve the problems of existing hydroxyapatite powder with large particle size, uneven particle size distribution and easy agglomeration in the preparation process

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  • Preparation method of nanometer hydroxyapatite powder

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Embodiment 1

[0031] A preparation method of nano-hydroxyapatite powder, comprising the following steps:

[0032] 1) preparing 160ml of phosphate ion solution with a concentration of 0.12mol / L, and adjusting the pH value of the phosphate ion solution to 10 with concentrated ammonia;

[0033] 2) Prepare 40ml of calcium ion solution with a concentration of 0.2004mol / L, and adjust the pH value of the calcium ion solution to 10 with concentrated ammonia water;

[0034] 3) The calcium ion solution is sprayed into the phosphate ion solution placed in an ultrasonic environment at a flow rate of 2ml / min after being atomized by ultrasonic spray, wherein, the ultrasonic spray atomization time of the calcium ion solution is 20min, and after all the calcium ion solution After the spraying is completed, the mixed solution is left to stand for half an hour to obtain hydroxyapatite precipitation;

[0035] 4) Pour the hydroxyapatite precipitate into a centrifuge tube, use ultrapure water and absolute etha...

Embodiment 2

[0037] A preparation method of nano-hydroxyapatite powder, comprising the following steps:

[0038] 1) Prepare 160ml of phosphate ion solution with a concentration of 0.12mol / L, and adjust the pH value of the phosphate ion solution to 10 with concentrated ammonia;

[0039] 2) Prepare 40ml of calcium ion solution with a concentration of 0.2004mol / L, and adjust the pH value of the calcium ion solution to 10 with concentrated ammonia water;

[0040] 3) The calcium ion solution is sprayed into the phosphate ion solution placed in an ultrasonic environment at a flow rate of 8ml / min after being atomized by ultrasonic spray, wherein, the ultrasonic spray atomization time of the calcium ion solution is 5min, and after all the calcium ion solution After the spraying is completed, the mixed solution is left to stand for half an hour to obtain hydroxyapatite precipitation;

[0041] 4) Pour the hydroxyapatite precipitate into a centrifuge tube, use ultrapure water and absolute ethanol an...

Embodiment 3

[0043] A preparation method of nano-hydroxyapatite powder, comprising the following steps:

[0044] 1) Prepare 160ml of phosphate ion solution with a concentration of 0.3mol / L, and adjust the pH value of the phosphate ion solution to 10 with concentrated ammonia;

[0045] 2) Prepare 40ml of calcium ion solution with a concentration of 0.501mol / L, and adjust the pH value of the calcium ion solution to 10 with concentrated ammonia water;

[0046] 3) The calcium ion solution is sprayed into the phosphate ion solution placed in an ultrasonic environment at a flow rate of 8ml / min after being atomized by ultrasonic spray, wherein, the ultrasonic spray atomization time of the calcium ion solution is 5min, and after all the calcium ion solution After the spraying is completed, the mixed solution is left to stand for half an hour to obtain hydroxyapatite precipitation;

[0047]4) Pour the hydroxyapatite precipitate into a centrifuge tube, use ultrapure water and absolute ethanol and w...

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Abstract

The invention provides a preparation method of nanometer hydroxyapatite powder. The preparation method comprises the following steps of (1) preparing a phosphate ion solution, and adjusting a pH value of the phosphate ion solution to be 10-12; (2) preparing a calcium ion solution, and adjusting a pH value of the calcium ion solution to be 10-12; (3) spraying the calcium ion solution into the phosphate ion solution, which is placed in an ultrasonic environment, at a certain flow rate after the calcium ion solution is atomized through ultrasonic atomizing, and then standing to obtain hydroxyapatite sediment; and (4) washing the hydroxyapatite sediment, and then conducting freeze drying to obtain the nanometer hydroxyapatite powder. According to the preparation method of the nanometer hydroxyapatite powder, an ultrasonic atomizing method in combination with a traditional ultrasonic method is used for synthesizing the nanometer hydroxyapatite powder which is small and uniform in particle size under conditions of a high concentration and room temperature.

Description

technical field [0001] The invention relates to the technical field of nano-powder preparation, in particular to a preparation method of nano-hydroxyapatite powder. Background technique [0002] Hydroxyapatite (HAP) is the inorganic component with the highest content in human bones. This material has good bioactivity and biocompatibility. HAP bioceramics can form strong chemical bonds with bones after implanted in the human body. It is an excellent material that can be used to replace human bones, and has good bone conduction effect and the effect of inducing new bone growth. However, the mechanical properties of hydroxyapatite ceramics are not good, and the low mechanical strength is the key point restricting its role in bone repair. Studies have shown that when the hydroxyapatite powder reaches the nanoscale, some mechanical properties of the synthesized HAP ceramics will be improved. Therefore, the preparation of nano-HAP powder is the main research direction now. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
CPCC01B25/32B82Y40/00C01P2004/64C01P2004/16C01P2004/10
Inventor 王欣宇张博文
Owner WUHAN UNIV OF TECH
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