Nanocapsule type polydopamine drug material and preparation method and application thereof

A technology of polydopamine and nanocapsules, which is applied in nanomedicine, nanotechnology, nanotechnology, etc., can solve the problems of high drug loading rate, difficult to achieve preparation, and only 10%, achieving good reproducibility, mild conditions, release-promoting effect

Active Publication Date: 2019-09-20
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation process of this method, strong acid or strong base is often used as an etchant, and the sacrificial templates used are mostly solid materials, and the drug loading rate of the post-loaded drug is generally only 10%, so it is difficult to achieve high drug-loaded preparation in one step. rate nanocapsule polydopamine drug

Method used

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  • Nanocapsule type polydopamine drug material and preparation method and application thereof
  • Nanocapsule type polydopamine drug material and preparation method and application thereof
  • Nanocapsule type polydopamine drug material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Follow the steps below to synthesize nano-encapsulated polydopamine drugs

[0026] According to the mass ratio of ZIF-8@ Adriamycin to dopamine of 1:2, then Tris-HCl (pH=8.8) solution was added, the final concentration of dopamine was 3mg / mL, and the mother liquor was obtained after ultrasound. The mother liquor was placed on a stirring reaction platform at 30°C and stirred for 48 hours, then taken out, centrifuged and freeze-dried to obtain a nanocapsule polydopamine drug with a drug size of 230 nm, a thickness of the polydopamine layer of 18 nm, and a drug load of 38%.

Embodiment 2

[0028] Follow the steps below to synthesize nano-encapsulated polydopamine drugs

[0029] According to the mass ratio of ZIF-8@cisplatin to dopamine of 1:1, Tris-HCl (pH=8.8) solution was added subsequently, the final concentration of dopamine was 2mg / mL, and the mother liquor was obtained after ultrasound. The mother liquor was placed on a stirring reaction platform at 25° C. and stirred for 72 hours, then taken out, centrifuged and freeze-dried to obtain a nanocapsule polydopamine drug with a size of 170 nm, a thickness of the polydopamine layer of 15 nm, and a drug load of 45%.

Embodiment 3

[0031] Follow the steps below to synthesize nano-encapsulated polydopamine drugs

[0032] According to the mass ratio of ZIF-8@paclitaxel to dopamine is 1:0.5, then Tris-HCl (pH=8.8) solution is added, the final concentration of dopamine is 0.5 mg / mL, and the mother liquor is obtained after ultrasound. The mother liquor was placed on a stirring reaction platform at 10°C and stirred for 72 hours, then taken out, centrifuged and freeze-dried to obtain a nanocapsule polydopamine drug with a size of 150nm, a thickness of the polydopamine layer of 5nm, and a drug loading of 43%.

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Abstract

The invention discloses a nanocapsule type polydopamine drug material and a preparation method and application thereof and belongs to the field of nano-drugs and preparation thereof. The nanocapsule type polydopamine drug material is prepared by a one-step synthesizing method. The preparation method has the advantages that an organic metal frame is used as the template to fix drugs, and accordingly drug loading capacity is increased greatly; the prepared nanocapsule type polydopamine drug material is high in drug loading capacity and capable of promoting drug release under near infrared mediation to achieve combined treatment; the preparation method is mild in conditions, low in requirements such as equipment requirements, operation requirements and environment requirements, economical in raw material, easy in raw material obtaining, easy to implement and good in stability and reproducibility.

Description

Technical field [0001] The invention belongs to the field of nano-medicine and its preparation, and specifically relates to a nano-capsule type polydopamine medicinal material and a preparation method and application thereof. Background technique [0002] Nano-polydopamine particles have many applications in tumor photothermal therapy and combined therapy due to their better water solubility, biocompatibility and good photothermal heating effect. The easy modification of its surface also broadens its application. Small molecule drugs can be modified on the surface of nano-polydopamine particles through chemical bond coupling to achieve the effect of combined therapy. However, the drug load in this aspect is relatively low, and it is difficult to reach the subcellular organelles for chemotherapy. [0003] Nano-encapsulated polydopamine is a new type of nano-polydopamine material, which has a hollow inner shell. Because the surface of the capsule polydopamine contains a large numbe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K41/00A61K47/34A61K45/00A61K9/19A61P35/00B82Y5/00B82Y40/00
CPCA61K9/19A61K9/5146A61K41/0042A61K41/0052A61K45/00A61P35/00B82Y5/00B82Y40/00A61K2300/00
Inventor 黄品同张涛
Owner ZHEJIANG UNIV
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