Unlock instant, AI-driven research and patent intelligence for your innovation.
Bifunctional polyurethane and its preparation method and application
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A polyurethane and dual-function technology, applied in prosthetics, medical science, etc., can solve problems such as the inability to eliminate oxidative stress at vascular implantation sites, achieve good processability and relieve oxidative stress
Active Publication Date: 2020-07-31
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
View PDF6 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0006] The purpose of the present invention is to solve the technical problem that the existing vascular materials cannot eliminate the oxidative stress of the vascular implantation site, and provide a dual-functional polyurethane and its preparation method and application
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0052] The preparation method of bifunctional polyurethane of the present invention comprises the following steps:
[0054] Step 2, adding small molecular polyols to the polyurethane prepolymer, reacting at 60-80°C for 3-6 hours, to obtain polyurethane with NCO groups at the end of the molecular chain;
[0055] Step 3: Add ligustrazine-nitrone capping agent to the polyurethane with NCO group at the end of the molecular chain, react at 60-80°C for 6-12h, precipitate in ether, wash with ether for several times, collect the white precipitate, and dry it in vacuum until Constant weight, obtains bifunctional polyurethane;
[0056] The structural formula of the ligustrazine-nitrone blocking agent is shown in formula III:
[0057]
[0058] In the above technical solutions, there are no spe...
Embodiment 1
[0074] Such as figure 2 Shown in (a), the synthesis of bifunctional polyurethane:
[0075] Step 1. Dissolve polycaprolactonepolyol (10g, molecular weight 2000 Daltons) in 200mL dry DMF, heat to 70°C, and add 2.52g hexamethylene diisocyanate dropwise under the protection of inert gas and 0.02g of stannous octoate was stirred at 70°C for 3h to obtain the first intermediate.
[0076] Step 2: Add 0.86 g of 1,4-butanediol in 10 mL of dry DMF dropwise to the first intermediate, and stir at 70° C. for 3 h after the addition is complete.
[0077] Step 3. Continue to add 10 mL of TBN-OH (0.47 g) DMF solution dropwise, and continue to react at 70°C for 12 hours, then precipitate the reaction solution in 1 L of ether, rinse with ether for 2-3 times, collect the white precipitate, and dry it in vacuum To constant weight, to obtain bifunctional polyurethane, denoted as PU-TBN.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention relates to difunctional polyurethane and a preparation method and application thereof, and belongs to the technical field of biologic medical materials. The technical problem that an existing blood vessel material cannot eliminate oxidative stress of a blood vesselimplant part is solved. The difunctional polyurethane contains a ligustrazine-nitrone group, and the structural formula of the ligustrazine-nitrone group is shown in the formula I. According to the difunctional polyurethane, by introducing a polyurethane molecular chain (tail end) into the ligustrazine-nitrone group with the dual functions of anti-oxidant and endothelial cell sticking promotion, the dual functions of polyurethane anti-oxidation and endothelial cell sticking promotion are given, adhesion and multiplication of endothelial cells can be effectively promoted, and the normal functions of the endothelial cells are promoted under the oxidation stress environment.
Description
technical field [0001] The invention relates to a bifunctional polyurethane and its preparation method and application, belonging to the technical field of biomedical materials. [0002] technical background [0003] In recent years, artificial blood vessels and stents have been widely used in the treatment of cardiovascular diseases. However, clinical studies have shown that due to the poor hemocompatibility of current vascular materials / stents, embolism and restenosis are prone to occur after implantation in the body, thus affecting the long-term application results. Since the vascular endothelium is a natural anticoagulant surface, it plays a vital role in the anticoagulation of blood vessels. Consequently, considerable research has been devoted to promoting rapid endothelialization of vascular materials. [0004] In the prior art, there are mainly four methods for promoting rapid endothelialization of vascular materials: in vitro endothelialization of artificial blood v...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More 
