A direct field optimization method and system based on fuzzy entropy

An optimization method and fuzzy entropy technology, applied in X-ray/γ-ray/particle irradiation therapy, radiotherapy, treatment and other directions, can solve problems such as large amount of calculation, improve accuracy, improve conformity, and reduce radiation dose Effect

Active Publication Date: 2022-04-22
ZHONGBEI UNIV
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Problems solved by technology

[0007] Aiming at the problems that using local gradient information to generate subfields will easily lead to local optimal results, and using global gradient information to generate subfields will cause a large amount of calculation, the present invention provides a method that can generate deliverable subfields more quickly and accurately. Direct Subfield Optimization Method and System of Fuzzy Entropy

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  • A direct field optimization method and system based on fuzzy entropy
  • A direct field optimization method and system based on fuzzy entropy
  • A direct field optimization method and system based on fuzzy entropy

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Embodiment Construction

[0106] A kind of direct sub-field optimization method based on fuzzy entropy of the present invention is implemented according to the following steps:

[0107] Step 1: Input the basic information required for direct subfield optimization, and calculate the gradient matrix of the subfield according to the objective function and other information in the input basic information;

[0108] Set the objective function as follows:

[0109]

[0110] Then the sub-objective function expression is:

[0111]

[0112]

[0113]

[0114]

[0115] f gEUD (D)=H(gEUD(D)-gEUD 0 )·(gEUD(D)-gEUD 0 );

[0116] f TCP (D)=H(TCP 0 -ln(TCP(D))) (TCP 0 -ln(TCP(D)));

[0117] f NTCP (D)=H(ln(1-NTCP 0)-ln(1-NTCP(D)))(ln(1-NTCP 0 )-ln(1-NTCP(D)));

[0118] in:

[0119] D(x) is the dose distribution, and D(x)=Wx, that is, the dose distribution is a linear function of the dose deposition matrix W and the fluence matrix x;

[0120] f l (D(x)) is the lth sub-objective function;

...

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Abstract

Aiming at the problems that using local gradient information to generate subfields will easily lead to local optimal results, and using global gradient information to generate subfields will cause a large amount of calculation, the present invention provides a method that can generate deliverable subfields more quickly and accurately. Fuzzy entropy direct sub-field optimization method and its system: First, the sub-field shape is generated based on the fuzzy entropy segmentation principle, and then the sub-field weight is optimized to obtain a treatment plan that meets clinical requirements. The present invention can quickly and accurately use the global gradient The subfield shape obtained from the information reduces the amount of calculation and improves the planning quality. The number of subfields obtained by optimization is small, which improves the optimization efficiency; The radiation dose received by the organs at risk and normal tissues around the area can be adjusted, so as to meet the clinical treatment requirements of increasing the therapeutic gain ratio, improving the accuracy of tumor radiation therapy, and reducing the probability of radiation-induced complications in normal tissues.

Description

technical field [0001] The invention relates to a direct field optimization method and system based on fuzzy entropy, belonging to the technical field of intelligent computing methods. Background technique [0002] Intensity-modulated radiation therapy is widely used in clinical cancer treatment. Intensity-modulated radiation therapy plan optimization adjusts the parameters of the irradiation field so that the shape of the high-dose area is basically consistent with the shape of the target area, and at the same time reduces the radiation dose received by the organs at risk and normal tissues around the target area as much as possible, so as to improve the accuracy of tumor radiation therapy. It is a clinical treatment requirement to reduce the probability of radiation-induced complications in normal tissues. [0003] The most widely used is the MLC intensity modulation technology. MLC intensity modulation technology mainly has two modes: static intensity modulation and dyn...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H20/40A61N5/10
CPCG16H20/40A61N5/1031A61N5/1039
Inventor 张丽媛张鹏程刘祎桂志国孟域朴
Owner ZHONGBEI UNIV
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