Application of patrinia herb extract in preparation of anti-drug resistant Acinetobacter baumannii drug

A technology of Acinetobacter baumannii and Patrinia, applied in antibacterial drugs, plant/algae/fungus/moss components, pharmaceutical formulations, etc., can solve the problem of no anti-drug-resistant bacteria, etc., and achieve a fast and effective method Bactericidal effect, cheap effect

A technology of Acinetobacter baumannii and Patrinia, applied in antibacterial drugs, plant/algae/fungus/moss components, pharmaceutical formulations, etc., can solve the problem of no anti-drug-resistant bacteria, etc., and achieve a fast and effective method Bactericidal effect, cheap effect

CN110302282AInactive Publication Date: 2019-10-08GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA
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  • Application of patrinia herb extract in preparation of anti-drug resistant Acinetobacter baumannii drug
  • Application of patrinia herb extract in preparation of anti-drug resistant Acinetobacter baumannii drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 Patrinia extract and the detection of its antibacterial activity

[0026] 1. Experimental method

[0027] 1. Preparation of Patrinia extract

[0028] Weigh three parts of Patrinia, each 2g, put them in three 100mL round bottom flasks respectively, add water, 50% ethanol, 95% ethanol three kinds of different solvents 24mL respectively according to the material ratio of 1:12; Flasks with different extraction solutions were set with different extraction temperatures of 100°C, 90°C, and 85°C, and were heated and refluxed for 1.5 hours to filter the medicinal solution; again, the corresponding extracts were added at a material ratio of 1:8, respectively, 100 Extract at ℃, 90℃, and 85℃ for 1.5 hours, filter and combine all the medicinal solutions, evaporate all the solvents under reduced pressure to obtain medicinal extracts, weigh them and place them in a 1.5mL centrifuge tube, and store them in a -20℃ refrigerator for later use. Three kinds...

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Abstract

The invention discloses an application of patrinia herb extract in preparation of an anti-drug resistant Acinetobacter baumannii drug. The application utilizes the patrinia herb extract to treat the nematode infected with the drug-resistant Acinetobacter baumannii, and shows that the patrinia herb extract has a good bactericidal effect on the drug-resistant Acinetobacter baumannii. The applicationprovides a good preliminary research basis for the development of new anti-drug resistant Acinetobacter baumannii drugs, and brings a dawn to solve the dilemma of no available medicine clinically fordrug-resistant Acinetobacter baumannii infection, the patrinia herb extract is used for prevention and treatment of the drug-resistant Acinetobacter baumannii, the method is fast, the price is cheap,and the operation is convenient.

Description

technical field [0001] The invention relates to the field of biotechnology, and more specifically, relates to the application of Patrinia extract in the preparation of anti-drug-resistant Acinetobacter baumannii medicaments. Background technique [0002] Acinetobacter baumannii is the most common non-fermenting Gram-negative bacterium in the Acinetobacter genus. The bacteria can survive for a long time in the hospital environment, and the distribution of clinical departments is mainly in the ICU, followed by the Department of Respiratory Medicine. Elderly patients, patients with weak body resistance and critical illness, as well as patients who use various invasive procedures and long-term treatment with broad-spectrum antibiotics are susceptible objects. Acinetobacter baumannii has the ability to rapidly acquire and spread drug resistance, drug-resistant Acinetobacter baumannii presents a worldwide epidemic trend, and has become one of the most important pathogenic bacteri...

Claims

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Application Information

Patent Timeline
08 Oct 2019
Publication
CN110302282A
IPC
A61K36/84; A61P31/04
CPC
A61K36/84; A61K2236/333; A61P31/04
Inventors
李健; 黄涛阳