ZIF-8@SiO2 core-shell spheres as well as preparation method and application thereof

A technology of ZIF-8 and microspheres, which can be used in measuring devices, instruments, scientific instruments, etc., can solve problems such as wide particle size distribution, poor reproducibility, and irregular shape of MOFs particles

Pending Publication Date: 2019-10-18
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the particle shape of MOFs synthesized by traditional methods is irregular, the particle size distribution is wide o

Method used

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  • ZIF-8@SiO2 core-shell spheres as well as preparation method and application thereof
  • ZIF-8@SiO2 core-shell spheres as well as preparation method and application thereof
  • ZIF-8@SiO2 core-shell spheres as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0033] 1. SiO2 2 Preparation of @ZIF-8 core-shell microspheres

[0034] 1. Amino modification on the surface of silica microspheres

[0035] Take 3 g of silica microspheres (2.5 μm diameter, Aladdin) and 150 mL of N,N-dimethylformamide (DMF) in a 250 mL round bottom flask, ultrasonically disperse for 10 min, and add 3 - Aminopropyltriethoxysilane (APTES) 3.48mL, then heated to 80°C, reacted for 12h; after the reaction was completed, the product was centrifuged (5000rpm, 6min), washed three times with DMF, then washed three times with ethanol, and the product was vacuum Dry to obtain amino-modified silica (SiO 2 -NH 2 ) about 3.3g.

[0036] 2. Carboxyl modification on the surface of silica microspheres

[0037] Take SiO 2 -NH 2 Powder 2.5g was dispersed in 40mL of DMF; 0.0123mol (1.203g) of maleic anhydride was dissolved in 40mL of DMF, and it was added dropwise to SiO2 -NH 2 In the dispersion liquid, stir and react for 12h. Centrifuge after the reaction (centrifugal c...

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Abstract

The invention discloses ZIF-8@SiO2 core-shell spheres. The ZIF-8@SiO2 core-shell spheres are composite microspheres having a core-shell structure in which SiO2 microspheres are taken as cores while ZIF-8 is taken as shells. The invention further provides a corresponding preparation method. The preparation method comprises the following steps: modifying SiO2 microspheres serving as cores with carboxyl to obtain SiO2-COOH; and then growing a zeolitic metal organic framework ZIF-8 shell layer on the surface layer by layer with a layer-by-layer alternative growth method. As proved by experiments,the composite microspheres have the characteristics of controllable coating thickness, regular appearance and high stability. The composite microspheres can be taken as a solid extraction material forpreparing an online solid extraction column, can be combined with high performance liquid chromatography for online enrichment detection of quinolone medicaments, has high repeatability and batch reproducibility, has high enriching performance for the quinolone medicaments, has the advantages of easiness, rapidness and efficiency in operation and small solvent dosage, and has a wide practical application prospect.

Description

technical field [0001] The invention belongs to the technical field of solid phase extraction materials, in particular to a ZIF-8@SiO 2 Core-shell microspheres and their preparation methods and applications. Background technique [0002] Quinolones antibiotics are a kind of synthetic antibacterial drugs with broad-spectrum antibacterial effect and strong antibacterial effect. They are mostly used as anti-infective drugs for veterinary diagnosis and treatment and aquaculture, and have played a good role. The frequency of bacterial innate resistance to quinolone antibiotics is extremely low, but acquired resistance develops rapidly, and quinolone antibiotics are likely to remain in animals, because these antibiotics cannot be fully absorbed and metabolized into Inactive substances excreted from the body can further enter the human body through the food chain and cause damage to human health. Quinolones antibiotics also have potential genotoxicity and carcinogenicity, threate...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/08G01N30/02
CPCG01N30/06G01N30/08G01N30/02G01N2030/062
Inventor 吴叶宇邢班彬
Owner GUANGXI UNIV FOR NATITIES
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