Caput humeri surface-replacement prosthesis in tissue engineering and making and installation methods of prosthesis

Abstract

The invention discloses a caput humeri surface-replacement prosthesis in tissue engineering and making and installation methods of the prosthesis. The caput humeri surface-replacement prosthesis comprises a caput humeri surface prosthesis body, the caput humeri surface prosthesis body loads a substrate material promoting bone and cartilage regeneration in a bracket obtained in the mode that an absorbable medical polymer material is subjected to 3D printing formation, by adopting a proper mode, micropores suitable for bones and cartilages to grow in are formed in the prosthesis body, and the prosthesis body is thick in center part and thin in periphery part; in cooperation with a handle and fixing lugs or in cooperation with a fixing device and the fixing lugs, the caput humeri surface prosthesis body is fixed to the surface of a caput humeri body; according to the caput humeri surface-replacement prosthesis, the surface of the caput humeri can be replaced with the prosthesis, the prosthesis has a good biomechanical property, after replacement, a rejection reaction cannot be generated, and many complications of prosthesis replacement are avoided; quick integration of the prosthesisand the caput humeri body can be achieved, integrated growth and no loosening are achieved, in the later use process, the revision problem does not exist, finally, no foreign body exists in the body,and the service life of the prosthesis is greatly prolonged.

Description

Technical field [0001] The invention specifically relates to a tissue engineering humeral head surface replacement prosthesis and a manufacturing and installation method thereof, and belongs to the technical field of medical devices. Background technique [0002] Artificial humeral head replacement is one of the effective methods for the treatment of complex proximal humeral fractures. It is suitable for patients with comminuted proximal humeral fractures; osteoarthritis; rotator cuff tear arthropathy. [0003] The authorization announcement number CN1226020C discloses a carbonaceous artificial humeral head prosthesis, which is a medical prosthesis. This carbon artificial humeral head prosthesis is composed of a carbon humeral head sphere and a humeral head stem. The angle between the central axis of the humeral head sphere articular surface and the center line of the humeral head stem is 135-145°. Its characteristics There is a bone graft hole on the upper part of the humeral hea...

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Problems solved by technology

[0004] The carbonaceous humeral head spheroid provided by the above device has good mechanical strength and chemical stability, light weight, wear-resistant and corrosion-resistant surface, no cytotoxicity, no sensitization, no genotoxicity, good biocompatibility, and elastic modulus similar to that of bone. , have osteogenic activity and lubricity; however, the wear debris and particles of the device can cause severe foreign body reactions, leading to bone resorption and damage to the normal bone structure. These wear particles can stimulate various phagocytic responses, secrete A variety of molecules related to bone resorption become an important reason for the loosening of prostheses in the later stage, and loosening will bring more serious wear and biological reactions

[0005] In addition to the above-mentioned carbon humeral head prosthesis, the humeral head prosthesis is generally made of metal, polyethylene and ceramics in the prior art; the metal humeral head prosthesis has good comprehensive mechanical properties and excellent processing performance, but metal As an inert material, it lacks a bioactive interface, and the interface has low bone formation ability, and there are problems such as corrosion in body fluids, resulting in loosening; the wear resistance of polyethylene humeral head prosthesis is insufficient, especially the debris generated after wear. The immune and biochemical reactions produced by macrophages and fibroblasts can promote osteoclasts to destroy the bone around the prosthesis, and eventually cause loosening and osteolysis. This factor has also become an important factor affecting the service life of the prosthesis; ceramic materials The brittleness of the humeral head prosthesis is relatively high, and it is easy to cause damage. Huge external force trauma, high-intensity load movement, and mismatched components can easily cause the ceramic humeral head prosthesis to break

[0006] In summary, the various humeral head prostheses in the prior art have rejection reactions, mismatch with the mechanical properties of the host bone, and problems in service life, which make it difficult to achieve satisfactory bone repair effects.

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