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Cosmetic composition comprising a combination of pongamia oil and 4-t-butylcyclohexanol for the treatment of rosacea

A technology of tert-butyl cyclohexanol and cosmetic composition, which is applied in the new combination field of water yellow bark oil and 4-tert-butyl cyclohexanol, and can solve problems such as side effects

Active Publication Date: 2019-10-29
PIERRE FABRE DERMO COSMETIQUE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been reported that the combination of treatments induces significant side effects, especially gastrointestinal and renal effects (Edwards, Br. J. Vener Dis., 56, 285-290, 1980)

Method used

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  • Cosmetic composition comprising a combination of pongamia oil and 4-t-butylcyclohexanol for the treatment of rosacea
  • Cosmetic composition comprising a combination of pongamia oil and 4-t-butylcyclohexanol for the treatment of rosacea
  • Cosmetic composition comprising a combination of pongamia oil and 4-t-butylcyclohexanol for the treatment of rosacea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Example 1: Pharmacological Tests of Combination of Pseudomonas Oil and 4-tert-Butylcyclohexanol in Pentanediol

[0091] The aim of this study was to evaluate the effect of the combination of pongamia oil and 4-tert-butylcyclohexanol in pentanediol on the inflammatory response of normal human epidermal keratinocytes in the rosacea environment (environnement de rosacée).

[0092] The rosacea environment was simulated by a mixture of three agonists as described in Steinhoff et al. 2013, JAAD; the three agonists being inflammatory mediators, innate immune mediators and bacterial components selected from TNF Activators, TLR2 (tool-like receptor) activators and TRP activators (TRPV1, TRPA1) and LL37 peptides.

[0093] plan

[0094] Water buffalo oil was evaluated at 10 µg / ml (equivalent to 0.001%), and pentanediol 4-tert-butylcyclohexanol was evaluated at 300 µM (corresponding to 47 µg / ml of 4-tert-butylcyclohexanol, thus 0.0047%). IKK inhibitors evaluated at 10 μM were us...

Embodiment 2

[0106] Example 2: Exemplary compositions according to the invention

[0107]

Embodiment 3

[0108] Example 3: Exemplary compositions according to the invention

[0109]

[0110]

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PUM

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Abstract

The present invention relates to the novel combination of pongamia oil and 4-t-butylcyclohexanol, and to the uses thereof in the fields of cosmetics and dermatology for the treatment of redness of theskin. More specifically, the present invention relates to the cosmetic use of a composition comprising said combination for the treatment of rosacea.

Description

technical field [0001] The present invention relates to a novel combination of pongamia oil and 4-tert-butylcyclohexanol and its use in the field of cosmetics and dermatology for combating redness. [0002] More specifically, the present invention relates to the cosmetic use of a composition comprising said combination for combating rosacea. Background technique [0003] The skin is the largest organ in the human body, accounting for nearly 2m 2 area. It plays a variety of fundamental roles, including protection from external influences, thermoregulation and hormone synthesis, and also has immune functions. The skin is composed of three superimposed layers: the epidermis (which is constantly renewed), the dermis and the hypodermis (which provides the fibrous structure). The color, texture and quality of the skin also have undeniable psychosocial functions. [0004] All types of sensitive skin are similar in that they react quickly and excessively to changes in temperatur...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K31/00A61P17/02
CPCA61K36/48A61K31/045A61K31/047A61K9/0014A61K47/02A61K47/10A61K47/12A61K47/14A61K47/183A61K47/22A61K9/06A61K47/32A61K47/34A61K9/08A61K47/36A61K9/10A61K9/12A61P17/00A61P17/02A61P29/00A61P43/00A61K2300/00A61K8/34A61K8/9789A61K8/922A61Q19/00A61K2800/5922A61K36/486
Inventor H·埃尔南德斯-皮金N·卡斯泰-里齐S·普瓦尼M·F·阿里耶斯Y·布律内尔
Owner PIERRE FABRE DERMO COSMETIQUE CORP
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