Cosmetic composition having effects of synergistically resisting oxidation

A cosmetic composition and anti-oxidation technology, applied in the direction of cosmetics, cosmetic preparations, drug combinations, etc., can solve the problems of no actual test, no synergy, cell membrane damage, etc., to improve the microcirculation system, increase the antioxidant capacity, Strengthens capillary walls

Inactive Publication Date: 2019-11-15
SHANGHAI NEW COGI COSMETIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. Destroy the cell membrane;
[0007] 2. Inactivate serum antiprotease;
[0008] 3. Damaged genes lead to the emergence and accumulation of cell mutations
[0015] 1) Many of them use a single reducing substance, but there is no actual test or it is not comprehensive enough for its specific antioxidant properties;
[0016] 2) Some use a variety of reducing substances, but either there is no synergy, just a simple combination, or the synergy experiment proves insufficient;
[0017] 3) Antioxidant cosmetics have stability problems and discoloration problems;
[0018] 4) The amount of antioxidants used in anti-oxidation cosmetics is not as high as possible, and some substances will have negative effects after being added in excess;
[0019] 5) Many antioxidant cosmetics do not take into account that the skin environment has both water and lipids, and the choice of antioxidants also needs to consider the balance of oil-water phase distribution

Method used

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  • Cosmetic composition having effects of synergistically resisting oxidation
  • Cosmetic composition having effects of synergistically resisting oxidation
  • Cosmetic composition having effects of synergistically resisting oxidation

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0074] The preparation method of the cosmetic composition of the above-mentioned embodiments 1-5 with synergistic antioxidant effect comprises the following steps:

[0075] 1) Add phase A into the water phase pot, stir and heat up to 85°C, homogenize and stir evenly;

[0076] 2) Add phase B into the oil phase pot, stir and melt completely;

[0077] 3) Add phases A and B into the emulsification pot for homogeneous emulsification for 8 minutes, keep warm and stir for 20 minutes;

[0078] 4) Stir the emulsification pot to cool down to 37°C, add phase C, and stir evenly.

[0079] 5) After passing the test, discharge the material.

[0080] The following is the content of the effect test example.

[0081] Because there are water and lipids in the human skin and cell environment, the selection of the composition needs to consider the distribution of the water phase and the oil phase. Free radicals involve the surface skin and deep skin, so the penetration of active ingredients mus...

Embodiment 1-5

[0090] Embodiment 1-5, comparative example.

[0091] 1.4 Test equipment

[0092] J124BC electronic analytical balance (Changshu Shuangjie Testing Instrument Factory); SW-CJ ultra-clean workbench (ThermoFisher Scientific); SS-01 UVB ultraviolet phototherapy instrument, Sigma Company; SynorgyHT microplate reader (BioTek Company, USA).

[0093] 2 test method

[0094] 2.1 DPPH. Free radical scavenging

[0095] 2.2 Cell recovery

[0096] 2.3 Cell culture

[0097] 2.4 UVB radiation

[0098] 2.5 MTT method to detect cell proliferation activity

[0099] 2.6 Detection of LPO content by enzyme-linked immunosorbent assay (ELISA)

[0100] 2.7 Data processing and statistical analysis methods (each experiment was repeated at least 3 times)

[0101] 3 test results

[0102] 3.1 The scavenging rate of the test sample to DPPH. free radicals is shown in Table 1 below:

[0103] Table 1 embodiment 1-5 and the clearance rate contrast table of matched group

[0104] group clear...

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PUM

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Abstract

The invention discloses a cosmetic composition having effects of synergistically resisting oxidation. The cosmetic composition comprises the following raw material components in percentage by weight of 0.1-6% of a myrothamnus flabellifolia leaf / stem extract, 0.01-0.8% of hydrolysis sodium hyaluronate, 0.01-0.6% of tocopherol, 0.01-0.6% of a palmitoyl tea extract and 92-99.87% of cosmetic auxiliarymaterial substrates. According to the cosmetic composition disclosed by the invention, various synergistically effective cosmetic raw materials are selected, so that preventive oxidation resistance and the efficacy of eliminating generated oxygen free radicals are taken into account, and the effect of safely, effectively and synergistically resisting oxidation can be achieved.

Description

technical field [0001] The invention relates to a skin care product, which belongs to the technical field of cosmetic production, in particular to a cosmetic composition with synergistic anti-oxidation effect and a preparation method thereof. Background technique [0002] We live in oxygen-rich air, which is what gives us life, but it also kills our healthy cells. Of course, it is not oxygen itself that directly kills cells, but a harmful substance called oxygen free radicals produced by it. [0003] Free radicals, also known as free radicals, are atoms or groups with unpaired electrons produced by the Homdytic Fission of a single substance or a compound. Its single electron has a strong tendency to pair, and tends to combine with other atomic groups in various ways to form a more stable structure, so free radicals are very active and become active intermediates in many reactions. [0004] Free radicals in the human body are divided into oxygen free radicals and non-oxygen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/67A61P39/06A61Q19/00A61Q19/08
CPCA61K8/9789A61K8/678A61K8/735A61Q19/00A61Q19/08A61P39/06
Inventor 闫继鹏李雪竹丛琳
Owner SHANGHAI NEW COGI COSMETIC
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