A reagent disk magnetic bead mixing device and its application method

A reagent disk and mixing technology, which is applied in the field of fully automatic magnetic particle chemiluminescence immunoassay analyzer equipment, can solve the problems of wear of moving parts of the reagent disk, reduced service life, and low success rate of scanning codes, etc., so as to shorten the experiment time and reduce the Wear and reduce the effect of rotation

Active Publication Date: 2020-02-07
山东康华生物医疗科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the previous design, the magnetic bead mixing large gear was fixed and installed, which required the entire reagent outer disk assembly to rotate back and forth to drive the magnetic bead mixing seat to rotate the mixing magnetic beads. This would cause that if the reagent arm rotated to the required When the sample is added, the outer ring assembly of the reagent tray has not turned to the corresponding position. At this time, the reagent arm must wait for the outer ring assembly of the reagent tray to turn to the correct position, and the reagent arm goes down to add samples, which will cause: 1. Every time the magnetic beads are mixed, the reagent plate needs to be rotated back and forth, and then returned to the reagent loading position, which will cause a long delay in the mixing of the magnetic beads, and will cause the luminometer reagent plate to over-period alarm and terminate the experiment. ;2. It is not conducive to shortening the experiment time of the entire luminometer in the later stage. The highlight of the luminometer is the fast and accurate results; 3. The moving parts of the reagent plate are severely worn and the service life is reduced; The scanning code does not recognize the phenomenon, the magnetic beads are in the middle circle, and the inner circle is blocked by reagent bottles with other components, which will cause the code scanning success rate to be too low

Method used

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  • A reagent disk magnetic bead mixing device and its application method
  • A reagent disk magnetic bead mixing device and its application method
  • A reagent disk magnetic bead mixing device and its application method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: as attached Figure 1-13 As shown, a reagent disk magnetic bead mixing device includes an outer disk 1, the bottom of the outer disk 1 is provided with a first gear 2, the upper part of the outer disk 1 is provided with a plurality of mixing seats 11, the mixing seats 11 A second gear 12 is connected, the second gear 12 is meshed with the first gear 2 , the first gear 2 is meshed with a third gear 21 , and the third gear 21 is connected with a first driving device 22 . The first driving device 22 drives the third gear 21 to rotate, the third gear 21 drives the first gear 2 to rotate, the first gear 2 drives the mixing base 11 to rotate, and the mixing base 11 contains the reagent mixed with magnetic beads, which needs to be adjusted. When the magnetic beads are mixed, it is only necessary to open the first drive device, and the mixing seat will rotate independently to mix the magnetic beads.

[0031] like Image 6 and Figure 9 As shown, the mixing seat 11...

Embodiment 2

[0041] Example 2: as Figure 1-13 As shown, the second driving device 141 and the third driving device 44 are turned on; the second driving device 141 drives the fifth gear 14 to rotate, the fifth gear 14 drives the fourth gear 13 to rotate, the fourth gear 13 drives the entire outer disk 1 to rotate, and the outer disk 1 Rotate to the sample adding position, and at the same time the inner disk 4 is also transferred to the sample adding position driven by the third drive device 44; turn on the first drive device 22, the first drive device 22 drives the third gear 21 to rotate, and the third gear 21 drives the first drive device 21 to rotate. A gear 2 rotates; the first gear 2 drives the second gear 12 meshed with it to rotate; the second gear 12 drives the mixing base 11 to rotate, and the magnetic beads in the mixing base 11 are mixed. , the barcode scanner 6 scans the barcode of the reagent in the mixing seat 11; the sample adding needle adds the sample. Such a design allow...

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PUM

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Abstract

The invention provides a reagent disk magnetic bead mixing device and its use method, comprising an outer disk, the bottom of the outer disk is provided with a first gear, the upper part of the outer disk is provided with a plurality of mixing seats, and the mixing seats are connected with A second gear, the second gear meshes with the first gear, the first gear meshes with a third gear, and the third gear is connected with the first driving device. The first driving device drives the third gear to rotate, the third gear drives the first gear to rotate, the first gear drives the mixing seat to rotate, and the mixing seat contains reagents mixed with magnetic beads. When the magnetic beads need to be mixed, Just turn on the first driving device, and the mixing seat will rotate independently to mix the magnetic beads. By using the first gear to drive multiple second gears to rotate at the same time, it drives the mixing seat to rotate to realize the mixing of magnetic beads, without relying on the rotation of the outer disk to achieve the mixing of magnetic beads, which shortens the experiment time and reduces the rotation of the outer disk , thereby reducing the wear of various components.

Description

technical field [0001] The invention relates to the technical field of automatic magnetic particle chemiluminescence immunoassay analyzer equipment, in particular to a reagent disk magnetic bead mixing device and a use method. Background technique [0002] Reagent mixing is an important breakthrough in the field of medical detection technology and an important part of the stability of chemiluminescence instruments. The quality of magnetic bead mixing will directly affect the experimental results. In the previous design, the magnetic bead mixing gear was fixedly installed, which required the entire reagent outer disk assembly to rotate back and forth to drive the magnetic bead mixing seat to rotate and mix the magnetic beads. When the sample is loaded, the outer ring assembly of the reagent tray has not been turned to the corresponding position. At this time, the reagent arm should wait for the outer ring assembly of the reagent tray to turn to the correct position, and then ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N35/00B01F9/00
CPCG01N35/00G01N35/00732G01N2035/00514B01F29/321B01F2101/23
Inventor 杨帆詹越波安倍莹姚凯伦李大伟葛玮
Owner 山东康华生物医疗科技股份有限公司
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