Method for uniformly mixing by adopting magnetic materials

A magnetic material and mixing technology, applied in the field of medical testing, can solve the problems of no disclosed method for mixing magnetic materials, complex structure, etc., and achieve the effects of good reaction results, simple and controllable methods, and improved efficiency.

Pending Publication Date: 2021-01-12
NANJING LANSION BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technical solution does not disclose the method of using magnetic materials for mixing, and discloses a magnetic bead stirring and mixing assembly with a relatively complicated structure

Method used

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  • Method for uniformly mixing by adopting magnetic materials
  • Method for uniformly mixing by adopting magnetic materials
  • Method for uniformly mixing by adopting magnetic materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]Embodiment 1: The method for mixing with magnetic materials specifically includes the following steps:

[0029](1) Choose a spherical mixing rotor made of iron as a magnetic material, with a diameter of 0.5mm, 10 pieces in total, ready to use;

[0030](2) Place the mixing rotor in the containing cavity containing the reaction solution;

[0031](3) A magnetic field is applied to the outside of the accommodating cavity, and the magnetic field is used to control the movement of the magnetic field position or / and control the strength of the magnetic field or / and control the direction of the magnetic field so that the mixing rotor is in the accommodating cavity The two ends of the inner part or the middle part of the containing cavity and the two ends of the containing cavity perform the physical movement back and forth, and the physical movement mode is rotation or translation or bounce; so as to achieve the effect of the substance in the liquid The purpose of mixing;

[0032]The specific rea...

Embodiment 2

[0033]Examples 2-7 all adopt the method of mixing with magnetic materials in the above-mentioned Example 1; the difference from Example 2 is that the mixing time and the standing time are different, and the reaction value is detected by the instrument immediately after the reaction. The measured Cy5 fluorescence values ​​are shown in Table 1.

[0034]Table 1 Cy5 fluorescence values ​​measured after the reactions in Examples 1-7

[0035]

[0036]It can be seen from Table 1 that the Cy5 fluorescence value measured after the reaction shows that the magnetic bead mixing can promote the antigen-antibody binding reaction. The longer the mixing time, the higher the reaction value. Among them, the reaction value is basically after 8 min. If it is stable, increase the mixing time, the reaction value will not increase much.

Embodiment 8

[0037]Embodiment 8: The difference from Embodiment 1 is that it also includes using Teflon for surface treatment on the surface of the mixing rotor to avoid adsorption;

[0038]The method for mixing with magnetic materials specifically includes the following steps:

[0039](1) Choose a spherical mixing rotor made of iron as a magnetic material, with a diameter of 0.5mm, 10 pieces in total, ready to use; Teflon is used for surface treatment on the surface of the mixing rotor to avoid adsorption;

[0040](2) Place the mixing rotor in the containing cavity containing the reaction solution;

[0041](3) A magnetic field is applied to the outside of the accommodating cavity, and the magnetic field is used to control the movement of the magnetic field position or / and control the strength of the magnetic field or / and control the direction of the magnetic field so that the mixing rotor is in the accommodating cavity The two ends of the inner part or the middle part of the containing cavity and the two e...

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Abstract

The invention discloses a method for uniformly mixing by adopting a magnetic material. The method specifically comprises the following steps: (1) selecting a magnetic material as a uniform mixing rotor; (2) putting the uniformly-mixing rotor into an accommodating cavity filled with a reaction solution; and (3) applying a magnetic field to the outside of the accommodating cavity, so that the uniform mixing rotor physically moves in the accommodating cavity to realize uniform mixing of the reaction solution. The method for uniformly mixing by adopting the magnetic material is suitable for the accommodating cavity, particularly a tiny accommodating cavity, the method is simple, the operation is controllable, and meanwhile, the uniform mixing reaction efficiency is improved.

Description

Technical field[0001]The invention belongs to the technical field of medical detection, and particularly relates to a method for mixing with magnetic materials.Background technique[0002]At present, with the advancement of science and technology, there are many mixing methods, but most of them are mixing in an open space. For example, mixing with a magnetic stirrer is to put a magneton in an open container with a reaction solution, and then Turn on the magnetic stirrer to apply a magnetic field to mix the reaction solution in the open container evenly. However, it is more difficult to mix the narrow-mouthed containing cavity or the nearly closed containing cavity or the containing cavity through which the opening and the solution storage cavity can not directly pass. Mix the sample to be tested in the contaminated container.[0003]Magnetic beads are commonly used raw materials in the fields of medical diagnosis and biological testing. Magnetic beads, also known as biomagnetic beads, r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/38B01F13/08
CPCG01N1/38G01N2001/386B01F33/45
Inventor 许行尚杰弗瑞·陈于沛
Owner NANJING LANSION BIOTECH CO LTD
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