Application of novel psoralea corylifolia isoflavone in preparation of medicines for preventing or treating postmenopausal osteoporosis

A new technology of psoralen isoflavones and osteoporosis, applied in the field of medicine

Pending Publication Date: 2019-11-22
SHANGHAI CHANGHAI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature reporting that the new psoralen isoflavone can inhibit osteoclastogenesis and treat postmenopausal osteoporosis, and there is no literature reporting its mechanism of action

Method used

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  • Application of novel psoralea corylifolia isoflavone in preparation of medicines for preventing or treating postmenopausal osteoporosis
  • Application of novel psoralea corylifolia isoflavone in preparation of medicines for preventing or treating postmenopausal osteoporosis
  • Application of novel psoralea corylifolia isoflavone in preparation of medicines for preventing or treating postmenopausal osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1. New psoralen isoflavone has inhibitory effect on bone loss after ovariectomy in C57 mice

[0031] 1. Experimental materials:

[0032] Physiological saline was used to dilute the new psoralen isoflavone into drug solutions with different concentrations.

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PUM

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Abstract

The invention relates to the technical field of medicine, in particular to an application of novel psoralea corylifolia isoflavone in preparation of medicines for preventing or treating postmenopausalosteoporosis, and a structure of the novel psoralea corylifolia isoflavone is shown as a formula I. The invention provides the novel application of the novel psoralea corylifolia isoflavone, and alsoprovides a novel thought for preventing and treating postmenopausal osteoporosis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of new psoralen isoflavones in the preparation of drugs for preventing or treating postmenopausal osteoporosis. Background technique [0002] New psoralen isoflavone is an isoflavone compound extracted from the Chinese herbal medicine psoraleae, which has various pharmacological effects such as anti-inflammatory and anti-tumor. In recent years, Neobavaisoflavone (Neobavaisoflavone, NBIF) has attracted great attention of researchers because of its significant anti-inflammatory and osteogenic activities in research and clinical practice. Ewelina et al. (Ewelina S, DariuszS, Czuba Z P, et al.Inhibition of Inflammatory Mediators by Neobavaisoflavonein Activated RAW264.7Macrophages[J].Molecules,2011,16(5):3701-3712.) reported in the new psoralen isoflavone Can inhibit the release of macrophage inflammatory mediators. Miing-Jaw et al. (Don M J, Lin L C, Chiou W F.Neo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P19/10A61P15/12
CPCA61K31/352A61P19/10A61P15/12
Inventor 陈辉文智信方超陈晓苏佳灿
Owner SHANGHAI CHANGHAI HOSPITAL
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