Preparation method of stable valdenafil hydrochloride trihydrate pharmaceutical composition

A technology of vardenafil hydrochloride and trihydrate, which is applied in the directions of drug combinations, active ingredients of heterocyclic compounds, sugar-coated pills, etc., can solve problems such as uneven weight gain of coating, and achieve the effect of improving stability
CN110507626AActive Publication Date: 2019-11-29SHANDONG CHUANGXIN PHARMA RES & DEV
8 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG CHUANGXIN PHARMA RES & DEV
Publication Date
2019-11-29

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a preparation method of a stable valdenafil hydrochloride trihydrate pharmaceutical composition. The method comprises the following steps: improving the water content of total medicinal auxiliary materials by 5.5-7.0 wt%, mixing valdenafil hydrochloride trihydrate with internally-added medicinal auxiliary materials, performing dry granulation, uniformly mixing granules obtained by the dry granulation with externally-added medicinal auxiliary materials, and performing tabletting and coating to obtain valdenafil hydrochloride tablets, wherein the total medicinal auxiliarymaterials comprise the internally-added medicinal auxiliary materials and the externally-added medicinal auxiliary materials. The preparation method disclosed by the invention improves the stability of the valdenafil hydrochloride trihydrate pharmaceutical composition on the premise of not influencing the dissolution of the preparation.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The disclosure relates to a preparation method of a stable vardenafil hydrochloride trihydrate pharmaceutical composition, belonging to the technical field of pharmaceutical preparations. Background technique

[0002] The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art.

[0003] Vardenafil hydrochloride trihydrate is a highly selective phosphodiesterase-5 inhibitor (PDE-5) developed and listed by German Bayer Pharmaceutical Company, which mainly exerts a therapeutic effect by specifically inhibiting the activity of PDE-5 enzyme. For the treatment of erectile dysfunction in men, it is the fastest-acting drug so far. Compared with similar products, the drug has the characteristics of rapid onset of action, long-lasting drug effect, good tolerance, small side effects, good safety, etc., and is convenient to take and is not affected by food and alcohol. After taking va...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More