Use of pentacyclic triterpenoids compounds in preparing bacterial hemolysin inhibitors

A technology of pentacyclic triterpenoids and compounds, which is applied in the field of medicine and pharmacy, and can solve problems such as pentacyclic triterpenoids that have not been reported in literature
CN110507660AInactive Publication Date: 2019-11-29JILIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JILIN UNIV
Publication Date
2019-11-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to use of pentacyclic triterpenoids compounds in preparing bacterial hemolysin inhibitors, provides a new use of pentacyclic triterpenoids compounds, and discloses that the pentacyclic triterpenoid compounds can neutralize the activity of bacterial hemolysin, reduce the damage of bacteria to host cells and the death caused by infection of model animals; inhibiting the activity of hemolysin can achieve the protective effect on the body; the pentacyclic triterpenoids compounds can be used to prepare drugs for hemolysin-producing bacterial infection.
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Description

technical field

[0001] The invention discloses the application of pentacyclic triterpenoids in the preparation of bacterial hemolysin inhibitors, provides a new application of pentacyclic triterpenoids, and belongs to the technical field of medicine and pharmacy. Background technique

[0002] The problem of bacterial drug resistance has become a hot spot in the world, among which Staphylococcus aureus is more serious. Drug-resistant bacterial infections lead to antibiotic treatment failure and high mortality, which has brought greater pressure to the treatment of nosocomial infections, especially the treatment of ICU infections. Bacteriolysin plays a vital role in the process of bacterial treatment of diseases. It is mainly manifested as causing damage to tissue cells, and can punch holes on the surface of cell membranes to destroy cells so that bacteria can obtain more nutrients. Ruptures red blood cells causing hemolysis. At present, the more studied hemolysins include S...

Claims

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