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Use of pentacyclic triterpenoids compounds in preparing bacterial hemolysin inhibitors

A technology of pentacyclic triterpenoids and compounds, which is applied in the field of medicine and pharmacy, and can solve problems such as pentacyclic triterpenoids that have not been reported in literature

Inactive Publication Date: 2019-11-29
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are no literature reports on pentacyclic triterpenoids as new hemolysin inhibitors after searching

Method used

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  • Use of pentacyclic triterpenoids compounds in preparing bacterial hemolysin inhibitors
  • Use of pentacyclic triterpenoids compounds in preparing bacterial hemolysin inhibitors
  • Use of pentacyclic triterpenoids compounds in preparing bacterial hemolysin inhibitors

Examples

Experimental program
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Embodiment 1

[0037] Pentacyclic triterpenoids are used as hemolysin inhibitors in any pharmaceutically acceptable carrier.

Embodiment 2

[0039] The pentacyclic triterpenoids are used as hemolysin inhibitors to prepare medicines for treating infectious diseases.

Embodiment 3

[0041] Pentacyclic triterpenoids are used as hemolysin inhibitors for the treatment of infectious diseases caused by bacteria.

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PUM

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Abstract

The invention relates to use of pentacyclic triterpenoids compounds in preparing bacterial hemolysin inhibitors, provides a new use of pentacyclic triterpenoids compounds, and discloses that the pentacyclic triterpenoid compounds can neutralize the activity of bacterial hemolysin, reduce the damage of bacteria to host cells and the death caused by infection of model animals; inhibiting the activity of hemolysin can achieve the protective effect on the body; the pentacyclic triterpenoids compounds can be used to prepare drugs for hemolysin-producing bacterial infection.

Description

technical field [0001] The invention discloses the application of pentacyclic triterpenoids in the preparation of bacterial hemolysin inhibitors, provides a new application of pentacyclic triterpenoids, and belongs to the technical field of medicine and pharmacy. Background technique [0002] The problem of bacterial drug resistance has become a hot spot in the world, among which Staphylococcus aureus is more serious. Drug-resistant bacterial infections lead to antibiotic treatment failure and high mortality, which has brought greater pressure to the treatment of nosocomial infections, especially the treatment of ICU infections. Bacteriolysin plays a vital role in the process of bacterial treatment of diseases. It is mainly manifested as causing damage to tissue cells, and can punch holes on the surface of cell membranes to destroy cells so that bacteria can obtain more nutrients. Ruptures red blood cells causing hemolysis. At present, the more studied hemolysins include S...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K31/58A61P31/04
CPCA61K31/56A61K31/58A61P31/04
Inventor 邓旭明周永林王建锋郭岩王大成牛效迪邱家章
Owner JILIN UNIV
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