A kind of medical biological gel hemostatic dressing and preparation method thereof

A technology of hemostatic dressing and biological gel, which is applied in the field of biomedicine, and can solve the problems that the speed and volume of hemostasis cannot meet the requirements of emergency treatment, bandages or bandages do not have ductility and stickiness, and cannot automatically apply pressure, etc. , to achieve the effect of improving peelability, preventing fracture and improving mechanical properties

Active Publication Date: 2020-07-03
山东速康医疗科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are defects in this type of operation mode: the one, because bandage or bandage do not have extensibility and viscosity, can not give compressive force automatically, so after fixing, bandage or bandage will lose compressive force if not tied tightly, if patient The movement may cause the gauze to shift; the second is that the gauze has poor blood-absorbing performance and is easy to infect the wound, and it only relies on the compressive force of the bandage or bandage to realize the compression of the wound
However, in the face of acute bleeding or surgical bleeding, its hemostatic speed and hemostatic volume still cannot meet the requirements of emergency treatment for a large amount of rapid bleeding
[0007] Therefore, it is a very important thing to invent a new type of hemostatic dressing that can solve the shortcomings of existing hemostatic dressings such as poor hemostatic effect, so as to adapt to the needs of relevant industries

Method used

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  • A kind of medical biological gel hemostatic dressing and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0035] A medical biogel hemostatic dressing, mainly comprising the following raw material components in parts by weight: 25 parts of silk, 10 parts of chitosan quaternary ammonium salt, 8 parts of bacterial cellulose, and 3 parts of polyacrylamide , 8 parts of sodium alginate, 12 parts of polyvinyl alcohol and 4 parts of nano silver.

[0036] A kind of preparation method of medical biogel hemostatic dressing, the preparation method of described medical biogel hemostatic dressing mainly comprises following preparation steps:

[0037] (1) Mix silkworm cocoons and sodium carbonate solution with a mass fraction of 10% at a mass ratio of 1:8, stir and react for 80 minutes at a temperature of 60°C and a rotational speed of 300r / min, and then filter to obtain degummed silkworm cocoons. After the silkworm cocoons were pulverized in a pulverizer for 40 minutes, thinned silk was obtained. The thinned silk and trypsin solution with a mass fraction of 3% were mixed in a beaker at a mass rat...

Embodiment 2

[0045] A medical biogel hemostatic dressing, mainly comprising the following raw material components in parts by weight: 25 parts of silk, 10 parts of chitosan quaternary ammonium salt, 8 parts of bacterial cellulose, and 3 parts of polyacrylamide , 12 parts of polyvinyl alcohol and 4 parts of nano silver.

[0046] A kind of preparation method of medical biogel hemostatic dressing, the preparation method of described medical biogel hemostatic dressing mainly comprises following preparation steps:

[0047] (1) Mix silkworm cocoons and sodium carbonate solution with a mass fraction of 10% at a mass ratio of 1:8, stir and react for 80 minutes at a temperature of 60°C and a rotational speed of 300r / min, and then filter to obtain degummed silkworm cocoons. After the silkworm cocoons were pulverized in a pulverizer for 40 minutes, thinned silk was obtained. The thinned silk and trypsin solution with a mass fraction of 3% were mixed in a beaker at a mass ratio of 1:12, and the temper...

Embodiment 3

[0055] A medical biogel hemostatic dressing, mainly comprising the following raw material components in parts by weight: 25 parts of silk, 8 parts of bacterial cellulose, 3 parts of polyacrylamide, 8 parts of sodium alginate, 12 parts of polyvinyl alcohol and 4 parts nano silver.

[0056] A kind of preparation method of medical biogel hemostatic dressing, the preparation method of described medical biogel hemostatic dressing mainly comprises following preparation steps:

[0057] (1) Mix silkworm cocoons and sodium carbonate solution with a mass fraction of 10% at a mass ratio of 1:8, stir and react for 80 minutes at a temperature of 60°C and a rotational speed of 300r / min, and then filter to obtain degummed silkworm cocoons. After the silkworm cocoons were pulverized in a pulverizer for 40 minutes, thinned silk was obtained. The thinned silk and trypsin solution with a mass fraction of 3% were mixed in a beaker at a mass ratio of 1:12, and the temperature was 36°C and the rota...

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Abstract

The invention discloses a medical biological gel hemostatic dressing and a preparation method thereof, which relate to the field of biomedicine. In the present invention, silkworm cocoons and polyvinyl alcohol solution are used to prepare silk protein mixed liquid, then bacterial cellulose is mixed with silk protein mixed liquid, polyacrylamide is added, and gel blank is obtained after freeze-thaw cycles; After the gel blank is treated with chitosan quaternary ammonium salt treatment solution, it is mixed with silver ammonia solution containing sodium alginate and calcium ion solution in turn, filtered, and freeze-dried to obtain a medical biological gel hemostatic dressing. The medical biogel hemostatic dressing prepared by the invention has excellent antibacterial properties, has good adsorption capacity for blood, and can rapidly coagulate the blood, and meanwhile, the medical biogel hemostatic dressing prepared by the invention has excellent mechanical properties.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a medical biogel hemostatic dressing and a preparation method thereof. Background technique [0002] Clinical medicine points out that if the human body does not take effective first aid measures due to acute bleeding, the patient will die within 6 to 20 minutes. If the blood loss of the human body exceeds 20% of the whole body's blood volume, shock will occur; if the blood loss exceeds 40% of the whole body's blood volume, it will be on the verge of death. According to statistics, the number of traumatic deaths accounts for 10% of the total number of deaths, and the death caused by massive hemorrhage accounts for 30% to 40% of them. Therefore, early control of hemorrhage is the main method to reduce mortality. [0003] At present, after various arteries and veins are punctured and extubated in a hospital, it is necessary to compress the wound to stop bleeding. The most widely used p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0014A61L26/0023A61L26/0057A61L26/0061A61L26/0066A61L26/008A61L2300/104A61L2300/232A61L2300/236A61L2300/404A61L2300/412A61L2400/04C08L5/08C08L1/02C08L33/26C08L5/04C08L29/04
Inventor 王倩倩杨鑫
Owner 山东速康医疗科技有限公司
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