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Traditional Chinese medicine composition for treating kawasaki disease, preparation and preparation method and application of preparation

A composition and technology for Kawasaki disease, applied in the field of medicine, can solve the problems of high treatment cost, aggravation of qi and yin injuries, etc., and achieve the effects of helping prognosis recovery, reducing the level of inflammatory factors, and inhibiting blood coagulation.

Inactive Publication Date: 2019-12-06
南京和昌睿生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned treatment costs are high, and some children do not respond to treatment; and long-term use of aspirin can cause obvious sweating, resulting in aggravation of qi and yin injuries during the recovery period

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Pulverization: Take 1.0kg of gypsum, 1.0kg of buffalo horn, 1.0kg of dandelion leaves, 0.5kg of forsythia, and 0.5kg of salvia miltiorrhiza, and pulverize them respectively. After passing through a 30-100 mesh sieve, mix the above medicinal powders to obtain medicinal materials to be extracted. powder;

[0025] (2) Extraction: add water to decoct the medicinal material powder obtained in step (1) twice, add 10 times the weight of the medicinal material powder for the first time and decoct for 1 hour, and add water 8 times the weight of the medicinal material powder to be extracted for the second time Boil for 1 hour, and combine the water decoction;

[0026] (3) Cool the water decoction obtained in step (2) and let stand overnight, filter and discard the precipitate, collect the filtrate and concentrate under reduced pressure to obtain an extract with a relative density of 1.10;

Embodiment 2

[0028] (1) Pulverization: Take 4.0kg of gypsum, 3.0kg of buffalo horn, 2.0kg of dandelion leaves, 1.5kg of forsythia, and 1.0kg of salvia miltiorrhiza in the prescription, and pulverize them respectively. Extract medicinal powder;

[0029] (2) Extraction: add water to decoct the medicinal material powder obtained in step (1) twice, add 10 times the weight of the medicinal material powder for the first time and decoct for 1 hour, and add water 8 times the weight of the medicinal material powder to be extracted for the second time Boil for 1 hour, and combine the water decoction;

[0030] (3) Cool the water decoction obtained in step (2) and let stand overnight, filter and discard the precipitate, collect the filtrate and concentrate under reduced pressure to obtain an extract with a relative density of 1.18.

Embodiment 3

[0032] (1) Pulverization: Take 4.0kg of gypsum, 3.0kg of buffalo horn, 2.0kg of dandelion leaves, 1.0kg of forsythia, and 0.5kg of salvia miltiorrhiza in the prescribed amount, and pulverize them respectively. Extract medicinal powder;

[0033] (2) Extraction: Add water to decoct the medicinal material powder obtained in step (1) twice, add 10 times the weight of the medicinal material powder to decoct for 6 hours for the first time, and add water 8 times the weight of the medicinal material powder to be extracted for the second time Boil for 6 hours, and combine the water decoction;

[0034] (3) Cool the water decoction obtained in step (2) and let stand overnight, filter and discard the precipitate, collect the filtrate and concentrate under reduced pressure to obtain an extract with a relative density of 1.24.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating kawasaki disease. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 6 parts of gypsum, 3 parts of cornu bubali, 4 parts of herba lophatheri, 3 parts of fructus forsythia and 2 parts of radix salviae miltiorrhizae. According to the traditional Chinese medicine composition, the gypsum clears heat and reduces fire, resolves the flesh and relieves exterior syndromes, promotes eruption and dissolves purpura, realizes detoxification and expels epidemic diseases, and engenders liquid and allays thirst; the cornu bubali clears heat, cools blood, realizes detoxification, and treats warm disease hyperpyrexia, macule generation, hematemesisand spontaneous external bleeding, and ulcer pyogenic infections; the herba lophatheri is cool and antipyretic, cools nutrients and protects yin, and contributes to prognostic recovery of pediatric patients; the fructus forsythia clears heat, realizes detoxification, removes stasis, realizes detumescence, can lower the inflammatory factor level, nourishes yin and generates body fluid, and clears away heart-fire and benefits the spleen; and the radix salviae miltiorrhizae promotes blood circulation to remove blood stasis, improves microcirculation, inhibits blood coagulation, activates fibrinolysis and inhibits thrombosis. The traditional Chinese medicine composition disclosed by the invention accords with the compatibility principles of various medicines, and the preparation of the traditional Chinese medicine composition can be used for treating kawasaki disease; and a formula is reasonable in compatibility and remarkable in effect, the cost is low, side effects are small, and clinical efficacy is remarkable.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating Kawasaki disease, belonging to the technical field of medicine. Background technique [0002] Kawasaki disease, also known as mucocutaneous lymph node syndrome, is an acute febrile rash pediatric disease with systemic vasculitis as the main lesion. It was first reported by Japanese doctor Kawasaki in 1967. The main harm is the formation of coronary artery dilatation and coronary aneurysm, which has become the primary cause of acquired heart disease in children. However, its etiology and pathogenesis are still unclear. Many studies have shown that Kawasaki disease may be a clinical syndrome caused by infection by one or more widespread pathogens and abnormal activation of the autoimmune system on the basis of certain genetic susceptibility. A series of bacterial viruses are related to Kawasaki disease, and the immune activation of the body is mediated by antigens or super...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P29/00A61P9/10A61P17/00A61K33/06A61K35/32
CPCA61K33/06A61K35/32A61K36/537A61K36/634A61K36/899A61K2236/331A61K2236/39A61P9/10A61P17/00A61P29/00A61K2300/00
Inventor 王和森张娟
Owner 南京和昌睿生物科技有限公司
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