A kind of measuring method of gm7237 to central nervous myelinization

Abstract

The invention belongs to the technical field of data detection, and discloses a method for measuring the myelination of the central nervous system by Gm7237. The drug used to treat CNS demyelination is gastrodin, which can significantly promote the formation of CNS myelination in a mouse model in vivo . By using high-throughput sequencing analysis, the present invention discovers the key long non-coding RNA Gm7237 that can enhance CNS myelination and is up-regulated by GAS. Through bioinformatics analysis and experimental verification, it was revealed that microRNA‑142a and its target myelin gene regulatory factor (MRF) were directly regulated by Gm7237. demonstrated that the Gm7237 / miR‑142a / MRF axis is a key pathway involved in CNS myelination mediated by GAS. The results of the present invention not only provide novel agents for the treatment of CNS demyelination, but also provide a molecular basis for GAS-promoted CNS myelination.

Description

technical field [0001] The invention belongs to the technical field of data detection, and in particular relates to a method for measuring central nervous myelination by Gm7237. Background technique [0002] Currently, the closest prior art: Central nervous system (CNS) demyelinating diseases, such as multiple sclerosis, neuromyelitis optica, and acute disseminated encephalomyelitis, affect millions of people worldwide. CNS demyelinating The main causes of sheathing include genetic abnormalities and inflammatory damage. During the pathological process of demyelination in the central nervous system, the myelin sheath degenerates and detaches from around the axons, resulting in severe damage to the structure and function of the central nervous system. Although the central nervous system The process of remyelination occurs spontaneously after demyelination, but remyelination often occurs in an inadequate or failed manner; therefore developing effective treatments for CNS demyel...

AI Technical Summary

Problems solved by technology

[0006] In summary, the existing problems in the prior art are: in the central nervous system during the pathological process of demyelination, the myelin sheath degenerates and detaches from around the axons, resulting in severe damage to the structure and function of the central nervous system. Although the central The process of remyelination occurs spontaneously following demyelination of the nervous system, but remyelination often occurs in an inadequate or abortive manner; experimental therapies developed using antibodies targeting remyelination inhibitors and stem cells that promote regeneration; still far from Did not meet safety and efficacy standards

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