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Method for screening biomarker for diagnosis of Alzheimer's disease

An Alzheimer's disease, biomarker technology, applied in the field of screening biomarkers for diagnosing Alzheimer's disease

Inactive Publication Date: 2019-12-13
AFFILIATED HOSPITAL OF GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of metabolites in OMVs from GM in AD is a key issue
But there are no studies on AD and OMVs in GM

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] research object

[0025] Feces were obtained from Alzheimer's disease patients (n=9) and healthy controls (n=9), both from the Affiliated Hospital of Guangdong Medical University (Zhanjiang, China). According to the diagnostic criteria for Alzheimer's disease, all patients underwent standardized diagnostic tests from the National Institute of Neurological and Communication Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association, with detailed medical histories, physical examinations, corresponding examinations, and functional assessments. Subjects with associated cerebrovascular disease or traumatic brain injury, unconscious subjects were excluded from the study. Informed consent was obtained from all persons before any data collection. The study was approved by the Ethics Committee of the Affiliated Hospital of Guangdong Medical University (Zhanjiang, China).

[0026] Extraction and purification of fecal bacteria outer membrane vesicles

[...

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Abstract

The invention belongs to the technical field of disease biomarker screening and particularly relates to a method for screening a biomarker for diagnosing Alzheimer's disease. The method comprises thefollowing steps of (S1) respectively obtaining excrement from an Alzheimer's disease patient and a health reference person, (S2) respectively extracting coprophilous fungus outer membrane vesicles ofthe excrement obtained in the step (S1) and purifying, (S3) respectively carrying out GC-MS analysis on metabolites of the coprophilous fungi outer membrane vesicles purified in the step (S2) by usinga gas chromatograph-mass spectrometer, and (S4) analyzing the GC-MS data obtained in the step S3 and screening out a differential metabolite, namely the biomarker for diagnosing the Alzheimer's disease. The method has great significance to the diagnosis of the Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of disease biomarker screening, and in particular relates to a method for screening biomarkers for diagnosing Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative disorder of uncertain etiology and pathogenesis that primarily affects older adults. With the aging population worldwide, the prevalence of AD is increasing rapidly and will be a heavy economic burden for all countries. Gut microbiota (GM) regulates the activation of glial cells through the gut microbiota-brain axis, and participates in the synaptic transmission of neurons and the metabolism of lipids in the brain. Metabolites produced by abnormal metabolism of gut microbiota can cause brain inflammation and immune response, and pathological changes can cause clinical manifestations, such as mental and behavioral abnormalities. Studies have shown that GM plays a pote...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/06
CPCG01N30/06G01N30/88G01N2030/8813
Inventor 刘洲魏守超彭万娟李康兰赵斌周海红
Owner AFFILIATED HOSPITAL OF GUANGDONG MEDICAL UNIV
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