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Packaging for dry tissue prosthetic heart valves

A heart valve and prosthesis technology, applied in the field of packaging of "dry" tissue prosthetic heart valves, can solve problems such as insufficiency, valve prosthesis tissue drying, regurgitation, etc.

Active Publication Date: 2022-08-09
MEDTRONIC VASCULAR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Possible problems with the valve include: stenosis, where the valve does not open properly; and / or incompetence or regurgitation, where the valve does not close properly
In other valve prosthesis packaging, the valve prosthesis is packaged in a dry compartment, however, it has been found that shipping, storage, and ethylene oxide (EtO) sterilization may dry out the valve prosthesis tissue under these conditions

Method used

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  • Packaging for dry tissue prosthetic heart valves
  • Packaging for dry tissue prosthetic heart valves
  • Packaging for dry tissue prosthetic heart valves

Examples

Experimental program
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Embodiment Construction

[0033] Specific embodiments of the present application are now described with reference to the drawings, wherein like reference numerals designate identical or functionally similar elements. The terms "distal" and "proximal" are used in the following description with respect to a position or orientation relative to the treating clinician. "Distal" or "distal" is a location or in a direction away from the clinician. "Proximal" and "proximal" are locations close to the clinician or in a direction toward the clinician. As used herein with reference to an implanted prosthetic heart valve, the terms "distal" and "outflow" are understood to mean downstream of the direction of blood flow, while the terms "proximal" or "inflow" are understood to mean blood flow upstream of the flow direction.

[0034] As mentioned herein, stented transcatheter prosthetic heart valves that may be used in and / or be part of various systems, devices, and methods may assume a variety of different configu...

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PUM

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Abstract

A "dry" package in which a prosthetic heart valve is packaged in a container with a hydrogel (116), which can be provided in a variety of forms. Certain embodiments include a hydrogel (116) preloaded with glycerol or the like. If there is a humidity gradient between the inside and the outside of the hydrogel, the hydrogel regulates the humidity inside the container through a diffusion-driven mechanism. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When a partially hydrated hydrogel (116) is present in a container filled with air of a predetermined humidity, if the air humidity is high (ie, when thermodynamics favor hydration of the hydrogel), water molecules from the air will be hydrogeled Glue absorbs and vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering a prosthetic heart valve.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This non-provisional patent application claims the benefit of the filing date of US Provisional Patent Application Serial No. 62 / 500,046, filed May 2, 2017, the entire teachings of which are incorporated herein by reference. Background technique [0003] The disclosed embodiments relate to packaging for "dry" tissue prosthetic heart valves, with or without a portion of a delivery device. Also disclosed are methods of packaging a transcatheter heart valve with or without a portion of a delivery device. [0004] The human heart consists of four heart valves, which determine the path blood flows through the heart: the mitral, tricuspid, aortic, and pulmonary valves. The mitral and tricuspid valves are atrioventricular valves located between the atria and ventricles, while the aortic and pulmonary valves are semilunar valves located in the arteries that leave the heart. Ideally, the native leaflets of the heart valve move a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B65D81/18A61F2/00B65D81/22A61F2/24
CPCA61F2/2412A61L2/206B65D81/18A61L2/08A61L2/208A61L2/26A61L2202/182A61L2202/21B65D81/22A61F2/0095A61F2/2418
Inventor R·瑞安D·克拉克K·加德Y·郭B·黄Y·达雷卡L·莱曼W·王L·麦克金利P·德威鲁克斯J·杜德尼T·蒂恩K·欧尔尼
Owner MEDTRONIC VASCULAR INC