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Diagnostic marker of Parkinson's disease and application thereof

A technology for diagnosing markers, Parkinson's disease, applied in disease diagnosis, biological testing, biological material analysis, etc., can solve problems such as inconvenience

Inactive Publication Date: 2019-12-27
于永鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, obtaining samples is an invasive operation, which is inconvenient

Method used

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  • Diagnostic marker of Parkinson's disease and application thereof
  • Diagnostic marker of Parkinson's disease and application thereof
  • Diagnostic marker of Parkinson's disease and application thereof

Examples

Experimental program
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Embodiment Construction

[0013] The embodiments listed in the present invention are only used to illustrate the present invention, but not to limit the scope of the present invention. Any obvious modifications or changes made to the present invention do not depart from the spirit and scope of the present invention.

[0014] This example is based on experiments to illustrate the relationship between kynurenine in urine and Parkinson's disease.

[0015] 1.1. Test preparation

[0016] Select 41 patients with Parkinson's disease as the PD group, and 41 healthy people with age and gender matching (P>0.05) as the control group. Collect the clean mid-stage urine in the morning with a 5ml sterile enzyme-free centrifuge tube and save it. The specimens were immediately centrifuged at 2-8°C (2500 rpm) for 20 minutes, and stored in a refrigerator at -80°C for 30 minutes. The age, gender, MMSE score, Hoehn-Yahr classification, course of disease, biochemical tests and other clinical indicators of all included patients w...

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Abstract

The invention relates to the field of biomedicine, and specifically to a diagnostic marker of a Parkinson's disease and application thereof. Up-regulated expression of kynurenine in the urine of a patient suffering from the Parkinson's disease is found for the first time, which suggests that the detection of expression level of the kynurenine has become one of the indicators for early diagnosis ofthe Parkinson's disease, thus confirming that the kynurenine can be used as a diagnostic marker of the Parkinson's disease, and providing a new direction for the diagnosis of the Parkinson's disease.

Description

Technical field [0001] The invention relates to the field of biomedicine, in particular to a diagnostic marker for Parkinson's disease and its application. Background technique [0002] Currently, effective markers for early diagnosis of Parkinson’s disease are imaging markers, that is, PET-CT and dopaminergic transporter tracers are used to detect the number of transporters for early diagnosis. This is because patients with Parkinson’s disease follow As the disease progresses, dopaminergic neurons are lost, dopamine transporters gradually decline, and the decline occurs in the early stage, which is different from the normal population, but the equipment is expensive and difficult to popularize, and there is a large dose of X-ray radiation. In addition, studies have also proposed the use of meta-benzioguanidine tracer to detect heart de-sympathetic innervation for early diagnosis of Parkinson’s disease, but it also involves the problem of PET-CT, which has X-ray radiation, expens...

Claims

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Application Information

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IPC IPC(8): G01N33/58G01N21/31
CPCG01N21/31G01N33/581G01N2800/2835
Inventor 于永鹏白家赫
Owner 于永鹏
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