Mesenchymal stem cell, therapeutic agent for immune disease, and Anti-inflammatory agent

Abstract

The present invention addresses the problem of providing a novel therapeutic agent for an immune disease and a novel therapeutic agent for an anti-inflammatory agent. The present invention which can solve the problem is a mesenchymal stem cell characterized by being capable of producing kynurenine in a large amount or capable of secreting kynurenine in a large amount. The present invention also includes a mesenchymal stem cell which is characterized by being capable of producing kynurenine, which is synthesized from tryptophan with IDO induced in a cell by the treatment with IFNgamma, in a large amount or being capable of secreting the kynurenine in a large amount, and a mesenchymal stem cell which is characterized in that the JAK / STAT pathway thereof is enhanced in a steady state.

Description

technical field

[0001] The present invention relates to mesenchymal stem cells, therapeutic agents for immune diseases and anti-inflammatory agents. Background technique

[0002] An immunodeficiency disorder is an infection that occurs because the immune system does not work properly, or has multiple recurrences, or worsens symptoms, or persists for a long time. In the case of an immunodeficiency disease, the ability of the immune system to protect the body from foreign enemies such as bacteria, viruses, and fungi, and from abnormal cells such as cancer cells, is impaired. As a result, infections and cancers caused by bacteria, viruses, and fungi that would not have occurred if the immune function was normal occur.

[0003] Among the immunodeficiency diseases, there are congenital (primary) immunodeficiency diseases contracted at birth, and acquired (secondary) immunodeficiency diseases developed later due to a certain disease or the like. Acquired immunodeficiency disease...

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