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Composition containing mixtures of pyridyl-aminopyrido-pyrimidine derivatives and application thereof

A kind of technology of pyridylaminopyridine and second pyridylaminopyridine, applied in the field of medicine, can solve the problems to be further improved and the like

Inactive Publication Date: 2019-12-31
黄泳华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, 2019, 10(03): 226-230.) The extracts of plants such as horn wind, six ear bells, rattan notoginseng, Guanzhong, golden thread grass, unipedal wind, eight hundred centimeters, and piercing stone have the effect on tobacco Ralstonia solanacearum at 100mg / L and / or 500mg / L Certain antibacterial activity, but the inventors found that the antibacterial activity of the above-mentioned plant extracts to other common pathogenic bacteria needs to be further improved

Method used

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  • Composition containing mixtures of pyridyl-aminopyrido-pyrimidine derivatives and application thereof
  • Composition containing mixtures of pyridyl-aminopyrido-pyrimidine derivatives and application thereof
  • Composition containing mixtures of pyridyl-aminopyrido-pyrimidine derivatives and application thereof

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Experimental program
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Effect test

preparation example 1

[0021] The preparation of preparation example 1 plant extract

[0022] Ultrasonic extraction method is used to dry the shade-dried plant material at 40°C, crush it, pass through a 40-mesh sieve, and put it into a ziplock bag. Before the test, 50 g of plant dry powder was weighed, and different organic solvents were added for ultrasonic extraction (as shown in Table 1), and the extraction was repeated 3 times for 60 min each time. Concentrate after filtration and store in a refrigerator at 4°C until use.

[0023] Table 1 Organic solution of ultrasonic extraction of different plant extracts

[0024] plant material Extract number Organic solvents wind PE1 n-heptane Fuji Sanchi PE2 Isopropanol Six ear bells PE3 Dichloromethane Eight hundred percent PE4 ethanol Bone style PE5 Methanol Gastrodia PE6 Chloroform Guan Zhong PE7 Isopropanol broken bone PE8 ethyl acetate Guangchamasma PE9 aceto...

Embodiment 1

[0100] Example 1 Preparation of Oral Solid Formulations Containing a Composition of Pyridylaminopyridopyrimidine Derivatives (1500 Unit Dosages)

[0101]

[0102] Note;

[0103] a NA stands for no added plant extracts

[0104] Preparation

[0105] Take the mixture X-Y-PEZ and auxiliary materials in the prescribed amount, and pass through a 100-mesh sieve. Take the mixture X-Y-PEZ, lactose, microcrystalline cellulose, crospovidone and starch and mix thoroughly; take the prescribed amount of hypromellose, and prepare a solution with a concentration of 10% based on hypromellose, Use lactic acid to adjust the pH to 3.0-4.0, add it to the above-mentioned mixture to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, fill the capsules, and obtain capsules;

[0106] Take the mixture X-Y-PEZ and auxiliary materials ...

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Abstract

The invention provides a composition containing mixtures of a first pyridyl-aminopyrido-pyrimidine derivative and a second pyridy-laminopyrido-pyrimidine derivative which are different from each other, and the pyridyl-aminopyrido-pyrimidine is defined as described in the specification. The mixtures of the pyridyl-aminopyrido-pyrimidine derivatives can produce a synergistic antibacterial effect with extracts from a plurality of plants such as lanceolate jasmine root or stem, Kadsura sP. root and rattan stem, illicium anisatum L., alpinia japonica rhizome, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition containing a mixture of pyridylaminopyridopyrimidine derivatives and its application. Background technique [0002] Nosocomial infection is an important issue affecting the quality of hospital care. With the continuous development and progress of modern medical technology, antibacterial drugs are widely used, and the drug-resistant strains of clinical pathogens are increasing. Therefore, improving the antibacterial activity of existing drugs will help to improve the therapeutic effect of patients with bacterial infections. [0003] CN108939081A discloses an antibacterial pharmaceutical composition containing metformin and a protein tyrosine kinase inhibitor, and discloses the antibacterial activity of the related protein tyrosine kinase inhibitor administered alone. The compound represented by formula I is a CDK kinase inhibitor. The inventors unexpec...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K36/9062A61K36/185A61K36/12A61K36/63A61K36/888A61K36/70A61K36/60A61K36/53A61K36/28A61K36/41A61K36/282A61K36/47A61K36/74A61K36/64A61K36/704A61K36/746A61K36/38A61K36/79A61K36/57A61K36/13A61K36/88A61K36/23A61P31/04
CPCA61K31/519A61K36/12A61K36/13A61K36/185A61K36/23A61K36/28A61K36/282A61K36/38A61K36/41A61K36/47A61K36/53A61K36/57A61K36/60A61K36/63A61K36/64A61K36/70A61K36/704A61K36/74A61K36/746A61K36/79A61K36/88A61K36/888A61K36/9062A61P31/04A61K2300/00Y02A50/30
Inventor 向飞雷莹
Owner 黄泳华
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