Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nerve matrix catheter for nerve repair and preparation method thereof

A nerve repair and nerve technology, applied in the field of nerve repair nerve matrix catheter and its preparation, can solve the problems of mismatched nerve size, non-degradable nerve repair catheter material, lack of autologous nerve transplantation sources, etc., to promote and induce nerve regeneration. , reducing immunogenicity, no immunogenicity excellent effect

Active Publication Date: 2019-12-31
CHONGQING UNIV OF TECH
View PDF9 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a nerve matrix conduit for long-distance nerve repair, which solves the problem of lack of sources for autologous nerve transplantation, size mismatch between donor and damaged nerve, and non-degradable nerve repair conduit Material needs secondary surgery and other issues

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nerve matrix catheter for nerve repair and preparation method thereof
  • Nerve matrix catheter for nerve repair and preparation method thereof
  • Nerve matrix catheter for nerve repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] One, a kind of natural nerve substrate catheter, adopts following method to make:

[0035] 1) Take the sciatic nerve from a healthy rat, and then bathe it in a Triton X-100 solution with a concentration of 3% (m / v) (which needs to be sterilized with a 0.22 μm filter membrane) at 50 r / v min speed for 12 hours, and change the water every 4 hours; after 12 hours, wash the nerve with distilled water for 2-3 times, and then place it in 3% (m / v) Triton X-100 solution for 12 hours; The nerve tissue was degreased with methanol for 24 h (the methanol solution was replaced twice during the period), and then the nerve tissue was treated with 2 μL / mL (v / v) DNase diluent at 37 °C for 2 h. Finally, the decellularized nerve tissue was obtained by washing and drying with absolute ethanol and water in sequence. After decellularization, the nerve tissue became loose, white strips, and slightly reduced in size ( figure 1 ).

[0036] 2) After the decellularized nerve tissue was crushed, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a nerve matrix catheter for nerve repair and a preparation method thereof. The catheter is formed by compounding and curing an acellular nerve matrix, chitosan and sodium glycerophosphate. The prepared natural gel matrix catheter is stable in structure and not prone to deformation and has the resilience of gel, and an inner diameter hole of the catheter is smooth and through. Moreover, the catheter has good temperature sensitivity and plasticity on the basis of meeting good biocompatibility, gelation occurs immediately when the temperature rises to the physiological body temperature of 37 DEG C, and the gelated catheter can be stored for a long time at the room temperature and meet different tissue requirements of the human body. The catheter has degradation controllability and is suitable for repairing different types of nerve defects; and the catheter has low immunity and nerve regeneration induction performance, and is beneficial to cell adhesion and acceleration of the nerve regeneration process. The preparation process is simple, easy to operate and control and wide in application prospect.

Description

technical field [0001] The invention relates to the technical field of tissue engineering materials, in particular to a nerve substrate conduit for nerve repair and a preparation method thereof. Background technique [0002] The repair and reconstruction of peripheral nerve defect is a major problem in the field of peripheral nerve injury. For short-segment nerve injuries, the severed nerve can be directly anastomosed end-to-end, so that the proximal regenerated nerve fibers can grow into the distal end. However, for long-segment nerve defects, it is currently impossible to repair them clinically. With the development of tissue engineering technology, the use of nerve guides and seed cells to construct tissue-engineered peripheral nerves in vitro to replace autologous nerve transplantation has become a development direction. [0003] The nerve conduit is a carrier for repairing nerve defects. It has the advantages of adjustable diameter and length, tension-free suture at t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/20A61L27/56A61L27/58
CPCA61L27/20A61L27/3604A61L27/3675A61L27/3687A61L27/56A61L27/58A61L2430/32C08L5/08
Inventor 陈国宝黄湘付强熊建夏斌王富平陈忠敏
Owner CHONGQING UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com