Construction of method for predicting schizophrenia sleep disorder (SD) improvement effect based on multiple antioxidant stress

Abstract

The present invention discloses a construction of a method for predicting a schizophrenia sleep disorder (SD) improvement effect based on multiple antioxidant stress. Blood plasma is collected beforetreatment, at an end of 2 weeks, at an end of 4 weeks and at an end of 6 weeks; the blood plasma is collected for detecting SOD and DHA; a HBO treatment is carried out on a patient once a day, 10 times are taken as one treatment course, an interval of each treatment course is 2 days, and total treatment courses are three; a polysomnography is used to monitor testees in patient wards respectively before starting the treatment and one week after finishing the treatment; a mathematical model is established according to concentrations of SOD and DHA in blood plasma for 4 times and sleep parametersobtained by monitoring whole-night sleep for 2 times before and after; and then the same testees are randomly selected as well, detection and monitoring are finished as well, and the mathematical model is repeatedly verified. An administration of hyperbaric oxygen can improve sleep disorder in overweight schizophrenia patients by influencing SOD enzyme activity and increasing DHA content.

Description

technical field [0001] The invention relates to the technical field of medicine and health, in particular to a method for predicting the SD improvement effect of schizophrenia based on multiple anti-oxidative stress constructions. Background technique [0002] Patients with schizophrenia often gain weight and suffer from sleep disorders. Sleep disorders are the precursor symptoms and accompanying symptoms of schizophrenia. The quality of sleep affects the outcome of the disease. Sleep disorders refer to the disrupted rhythm of sleep and wakefulness or the abnormal amount of sleep and abnormal behaviors during sleep, including insomnia. Patients with schizophrenia have a high level of oxidative stress, and oxidative stress (Oxidative Stress, OS) is caused by the imbalance between the production of reactive oxygen species (Reactive oxygen species, ROS) and antioxidants that can reduce ROS. The imbalance of oxidation and anti-oxidation in the body, normal level of OS helps the...

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Problems solved by technology

[0005] The purpose of the present invention is to provide a method based on multiple anti-oxidative stress construction to predict the improvement effect of schizophrenia SD. The administration of hyperbaric oxygen (HBO) can significantly improve the activity of SOD enzyme in brain tissue and increase the content of DHA. It can improve the sleep disturbance of overweight patients with schizophrenia by affecting the activity of SOD enzyme and increasing the content of DHA, which solves the problem that the existing anti-schizophrenia drugs cannot comprehensively and effectively improve the sleep disturbance of patients

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